1.1.1.272: D-2-hydroxyacid dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about D-2-hydroxyacid dehydrogenase (NADP+), go to the full flat file.
Word Map on EC 1.1.1.272
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1.1.1.272
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dehydrogenases
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2-hydroxyacids
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enterococcus
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nad-dependent
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d-mandelate
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2-oxobutyric
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d-lactate
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2-ketoisocaproate
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knowledgebase
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delbrueckii
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2-keto
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4-methylthio
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benzoylformate
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haloferax
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glyoxylate
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bulgaricus
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faecium
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d-2-hydroxyisocaproate
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mediterranei
- 1.1.1.272
- dehydrogenases
-
2-hydroxyacids
-
enterococcus
-
nad-dependent
- d-mandelate
-
2-oxobutyric
- d-lactate
- 2-ketoisocaproate
-
knowledgebase
- delbrueckii
-
2-keto
-
4-methylthio
- benzoylformate
-
haloferax
- glyoxylate
- bulgaricus
- faecium
-
d-2-hydroxyisocaproate
- mediterranei
Reaction
Synonyms
(R)-2-hydroxyacid dehydrogenase, (R)-sulfolactate dehydrogenase, (R)-sulfolactate:NAD(P)+ oxidoreductase, 2-D-hydroxyacid dehydrogenase, 2-HDH, 2HADH, D-2-hydroxyacid dehydrogenase, D-isomer specific 2-hydroxyacid dehydrogenase, D2-HDH, DDH, DDH_HALMT, HDH, L-2-hydroxyacid dehydrogenase, L-sulfolactate dehydrogenase
ECTree
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Crystallization
Crystallization on EC 1.1.1.272 - D-2-hydroxyacid dehydrogenase (NADP+)
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free enzyme, to 3.0 A resolution, and the nonproductive ternary complex with alpha-ketohexanoic acid and NAD+ to 2.0 A resolution, by hanging-drop vapour-diffusion method
three crystal structures of DDH_HALMT are solved in complex with combinations of NAD+, NADP+, NADPH, 2-ketohexanoic acid, and 2-hydroxyhexanoic acid (PDB IDs are 5mha, 5mh5, 5mh6)
purified recombinant enzyme, sitting drop vapour diffusion method, mixing of 0.001 ml of 30 mg/ml protein in 25 mM Tris/HCl, pH 8.0, 0.3 M NaCl, and 1 mM dithiothreitol, with 0.001 ml of reservoir solution containing 23% w/v PEG 3350, 0.2 M MgCl2, and 0.1 M HEPES, pH 7.0, and equilibration against 0.1 ml of reservoir solution, 20°C, X-ray diffraction structure determination and analysis at 1.64 A resolution, molecular replacement and modeling
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