1.1.1.271: GDP-L-fucose synthase

This is an abbreviated version!
For detailed information about GDP-L-fucose synthase, go to the full flat file.

Word Map on EC 1.1.1.271

1.1.1.271

fucosylation

gdp-d-mannose

4,6-dehydratase

k-dependent

gdp-d-mannose-4,6-dehydratase

nadph-binding

synthesis

Reaction

Synonyms

fcl, FX protein, GDP-4-keto-6-D-deoxymannose epimerase-reductase, GDP-4-keto-6-deoxy-D-mannose epimerase-reductase, GDP-4-keto-6-deoxy-D-mannose epimerase/reductase, GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase, GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase/reductase, GDP-4-keto-6-deoxy-mannose-3,5-epimerase-4-reductase, GDP-4-keto-6-deoxymannose 3, 5-epimerase 4-reductase, GDP-4-keto-6-deoxymannose 3,5-epimerase 4-reductase, GDP-4-keto-6-deoxymannose 3,5-epimerase-4-reductase, GDP-4-keto-6-deoxymannose epimerase-reductase, GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase, GDP-D-mannose-4,6-dehydratase, GDP-Fuc synthase, GDP-fucose synthase, GDP-fucose synthetase, GDP-fucose-synthesizing enzyme FX, GDP-keto-6-deoxymannose 3,5-epimerase/4-reductase, GDP-L-fucose synthetase, GDPFuc synthase, GER, GFS, GMER, guanosine diphosphofucose synthetase, P35B tumour rejection antigen, PF3D7_1014000, Red cell NADP(H)-binding protein, Transplantation antigen P35B, TSTA3, Tum-P35B antigen, wcaG

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.271 GDP-L-fucose synthase

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Results	in table
2	Activating Compound
18129	AA Sequence
2	Application
1	CAS Registry Number
19	Cloned(Commentary)
22	Cofactor
4	Crystallization (Commentary)
87	Disease/ Diagnostics
2	Expression
2	General Information
8	Inhibitors
3	Ki Value [mM]
10	KM Value [mM]
2	Localization
3	Metals/Ions
11	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
29	Organism
4	Pathway
36	PDB ID
3	pH Optimum
3	pH Range
12	Protein Variants
9	Purification (Commentary)
1	Reaction
3	Reaction Type
28	Reference
11	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
31	Substrates and Products (Substrate)
5	Subunits
59	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Range [°C]
1	Temperature Stability [°C]
6	Turnover Number [1/s]

Cloned

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Cloned on EC 1.1.1.271 - GDP-L-fucose synthase

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4 entries

DNA and amino acid sequence determination and analysis, enzyme expression in Mycobacterium bovis leads to restoration of wild-type phenotype producing triglycosylated phenolic glycolipids instead of monoglycosylated as in the mutant, mass spectrometric lipid spectrum analysis, overview

Mycobacterium tuberculosis

687711

expressed in Escherichia coli

4 entries

expressed in Saccharomyces cerevisiae

2 entries

expression in Agrobacterium tumefaciens

Arabidopsis thaliana

O49213, Q9LMU0

700488

expression in Escherichia coli

Plasmodium falciparum

A0A143ZXB3

740708

expression of the His-tagged enzyme in Escherichia coli strain BL21 (DE3)

Mortierella alpina

D3JU54

702081

four genes (manB, manC, gmd, and wcaG) cloned from Escherichia coli are expressed in Lactococcus lactis

Escherichia coli

P32055

763292

gene fx, expression of the N-terminally His6-tagged enzyme in Escherichia coli

Homo sapiens

723814

gene wcaG, overexpression in strain BL21(DE3) together with GDP-D-mannose-4,6-dehydratase

Escherichia coli K-12

677753

quantitative RT-PCR expression analysis of the enzyme in liver and hepatocarcinomas, overview

Homo sapiens

673885

wild-type and mutants introduced into the pT7GFS vector. Plasmid encodes for the expression of GFS bearing N-terminal hexahistidine tags, expressed in Escherichia coli BL21 (DE3)

Escherichia coli K-12

698467