1.1.1.270: 3beta-hydroxysteroid 3-dehydrogenase

This is an abbreviated version!
For detailed information about 3beta-hydroxysteroid 3-dehydrogenase, go to the full flat file.

Reaction

Synonyms

17beta-HSD7, 17beta-hydroxysteroid dehydrogenase type 7, 3-keto reducing enzyme, 3-keto reductase, 3-keto-reductase, 3-ketoreductase, 3-ketosteroid reductase, 3-KSR, 3-oxo steroid reductase, 3-oxosteroid reductase, 3beta-HSD, 3beta-HSD1, 3beta-HSD2, 3beta-HSDH, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase type 1, 3beta-hydroxysteroid dehydrogenase/Delta 5->4-isomerase type 1, 3beta-hydroxysteroid dehydrogenase/Delta 5->4-isomerase type 2, 3beta-hydroxysteroid dehydrogenase/isomerase, AKR1C1, AKR1C2, AKR1Cs, aldo-keto reductase 1C2, CDD59473, Erg27, Erg27p, Hsd17, HSD17B7, HSD3B1, reductase, 3-oxo steroid, reductive 3beta-HSD, SDR11E1, SDR11E2, steroid-3-ketoreductase, sterol 3-ketoreductase, sterone-reducing enzyme, type 3 3alpha-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase

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4	Activating Compound
363	AA Sequence
3	Application
1	CAS Registry Number
11	Cloned(Commentary)
27	Cofactor
878	Disease/ Diagnostics
1	Expression
22	General Information
4	General Stability
15	IC50 Value
37	Inhibitors
8	kcat/KM [mM/s]
10	Ki Value [mM]
43	KM Value [mM]
19	Localization
1	Metals/Ions
3	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
32	Organism
14	Pathway
8	pH Optimum
19	Protein Variants
5	Purification (Commentary)
4	Reaction
3	Reaction Type
30	Reference
46	Source Tissue
5	Specific Activity [micromol/min/mg]
140	Substrates and Products (Substrate)
1	Subunits
52	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
2	Temperature Stability [°C]
32	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.1.1.270 - 3beta-hydroxysteroid 3-dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

3beta-hydroxysteroid:NADP+ 3-oxidoreductase

The enzyme acts on multiple 3beta-hydroxysteroids. Participates in the biosynthesis of zemosterol and cholesterol, where it catalyses the reaction in the opposite direction to that shown. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.62, 17beta-estradiol 17-dehydrogenase [4].