1.1.1.267: 1-deoxy-D-xylulose-5-phosphate reductoisomerase

This is an abbreviated version!
For detailed information about 1-deoxy-D-xylulose-5-phosphate reductoisomerase, go to the full flat file.

Reaction

Synonyms

1-deoxy-D-xylulose 5-phosphate isomeroreductase, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 1-deoxy-D-xylulose-5-phosphate, 1-deoxy-D-xylulose-5-phosphate reductoisomerase, 1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose 5-phosphate reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase, 2C-methyl-D-erythritol 4-phosphate synthase, 2C-methyl-D-erythritol-4-phosphate synthase, AaDXR, CaDXR, deoxyxylulose 5-phosphate reductoisomerase, deoxyxylulosephosphate reductoisomerase, DOXP reductoisomerase, DOXP-reductoisomerase, DXP reductoisomerase, DXP-reductoisomerase, DXR, DXR1, DzDXR, EcDXR, FtIspC, IspC, MEP synthase, meps, methylerythritol phosphate synthase, MtbIspC, MtDXR, Os01g01710, OsDXR, PdDXR, PfDXR, PtDXR, Rv2870c, SaDXR, VvDxr, YpIspC

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.267 1-deoxy-D-xylulose-5-phosphate reductoisomerase

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Results	in table
7	Activating Compound
35608	AA Sequence
29	Application
1	CAS Registry Number
58	Cloned(Commentary)
106	Cofactor
16	Crystallization (Commentary)
10	Expression
64	General Information
162	IC50 Value
385	Inhibitors
14	kcat/KM [mM/s]
64	Ki Value [mM]
85	KM Value [mM]
21	Localization
76	Metals/Ions
24	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
540	Organism
7	Pathway
136	PDB ID
30	pH Optimum
1	pH Range
1	pH Stability
6	pI Value
4	Posttranslational Modification
47	Protein Variants
28	Purification (Commentary)
14	Reaction
3	Reaction Type
134	Reference
92	Source Tissue
8	Specific Activity [micromol/min/mg]
8	Storage Stability
141	Substrates and Products (Substrate)
29	Subunits
190	Synonyms
1	Systematic Name
29	Temperature Optimum [°C]
2	Temperature Range [°C]
4	Temperature Stability [°C]
36	Turnover Number [1/s]

Natural Substrates Products

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of the Enzyme Summary Page.

Natural Substrates Products on EC 1.1.1.267 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

54 entries

additional information

?

-

Arabidopsis thaliana

Q9XFS9

participation in the control of the 2-C-methyl-D-erythritol 4-phosphate pathway

657038

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Arabidopsis thaliana

Q9XFS9

second committed step in isopentenyl diphosphate biosynthesis via the plastidial nonmevalonate pathway of isoprenoid biosynthesis, overview

676579

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Arabidopsis thaliana

Q9XFS9

second step of the deoxyxylulose 5-phosphate/methylerythritol 4-phosphate pathway with end product isopentenylphosphate

673562

-

-

r

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Artemisia annua

Q9SP64

-

763576

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Catharanthus roseus

-

-

763607

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Centella asiatica

A0A0A6Z621

-

762525

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Digitalis purpurea

-

-

763181

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Dioscorea zingiberensis

A0A1P8JPV2

-

762782

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Escherichia coli

-

-

723812

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Escherichia coli

-

-

286421

-

286421

ir

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Escherichia coli

-

-

286422

-

286422

ir

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Escherichia coli

-

-

286423

-

286423

ir

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Escherichia coli

-

-

286427

-

286427

ir

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Escherichia coli

-

-

672040, 675577

-

-

r

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Escherichia coli

P45568

-

762667, 762794, 763000, 763482

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Escherichia coli

-

-

763482

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Escherichia coli

P45568

-

286428

-

286428

ir

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Escherichia coli

-

involved in the biosynthesis of isopentenylphosphate

675580

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Escherichia coli

P45568

key enzyme in the bacterial nonmevalonate pathway to terpenoids, DXR introduces the key branching structure required for the eventual production of isopentenyl diphosphate

673073

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Francisella tularensis subsp. novicida

A0Q7Y5

-

760333

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Francisella tularensis subsp. novicida U112

A0Q7Y5

-

760333

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Ginkgo biloba

Q5J7B3

the enzyme catalyzes the second committed step in the 2C-methyl-D-erythritol 4-phosphate pathway for biosynthesis of isopentenyl diphosphate

676736

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Mentha x piperita

-

-

286420

-

286420

ir

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Mentha x piperita

-

-

286426

-

286426

ir

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Mycobacterium tuberculosis

-

-

724346, 724374, 725564

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Mycobacterium tuberculosis

P9WNS1

-

725663, 760333, 763000

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Mycobacterium tuberculosis

-

first committed step in the mevalonate-independent isopentenyl diphosphate biosynthetic pathway, overview

674260

-

-

r

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Mycobacterium tuberculosis

-

second step of the deoxyxylulose 5-phosphate/methylerythritol 4-phosphate pathway with end product isopentenylphosphate

671075

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Mycobacterium tuberculosis ATCC 25618

P9WNS1

-

760333, 763000

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Mycobacterium tuberculosis H37Rv

-

first committed step in the mevalonate-independent isopentenyl diphosphate biosynthetic pathway, overview

674260

-

-

r

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Mycobacterium tuberculosis H37Rv

-

second step of the deoxyxylulose 5-phosphate/methylerythritol 4-phosphate pathway with end product isopentenylphosphate

671075

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Mycobacterium tuberculosis H37Rv

P9WNS1

-

725663, 760333, 763000

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Mycolicibacterium smegmatis

A0QVH7

-

762794

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Mycolicibacterium smegmatis ATCC 700084

A0QVH7

-

762794

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Oryza sativa Japonica Group

Q8W250

-

762871

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Plasmodium falciparum

-

-

286429

-

286429

ir

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Plasmodium falciparum

O96693

-

723812

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Plasmodium falciparum

Q8IKG4

-

763000, 763279, 763547

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Plasmodium falciparum

-

-

763547

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Plasmodium falciparum

O96693

second step of the deoxyxylulose 5-phosphate/methylerythritol 4-phosphate pathway with end product isopentenylphosphate, overview

675038

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Plectranthus barbatus

Q6R3F4

the enzyme catalyzes the first committed step in the biosynthesis of isopentenyl diphosphate in the plastidial 2C-methyl-D-erythritol 4-phosphate pathway leading to production of forskolin, overview

676660

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Populus trichocarpa

A0A2K1XJL6

-

763591

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Pseudomonas aeruginosa

-

-

286425

-

286425

ir

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Santalum album

MH018577

-

763120

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Synechocystis sp.

-

-

671590

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Synechocystis sp.

-

second step of the methylerythritol 4-phosphate pathway

672396

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Synechocystis sp.

-

step in the methylerythritol 4-phosphate pathway

672538

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Thymus vulgaris

A0A1U9X9N3

-

748373

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Toxoplasma gondii

-

-

724543

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Vibrio vulnificus

Q8DBF5

-

762747

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Vibrio vulnificus CMCP6

Q8DBF5

-

762747

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Wurfbainia villosa

C6G1Y8

-

720429

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Yersinia pestis

Q8ZH62

-

760333

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Yersinia pestis A1122

Q8ZH62

-

760333

-

-

?

1-deoxy-D-xylulose 5-phosphate + NADPH + H+

2-C-methyl-D-erythritol 4-phosphate + NADP+

Zymomonas mobilis

-

-

286424

-

286424

ir