1.1.1.265: 3-methylbutanal reductase

This is an abbreviated version!
For detailed information about 3-methylbutanal reductase, go to the full flat file.

Reaction

Synonyms

3-methylbutyraldehyde reductase, aldehyde reductase, bcADH, branched-chain alcohol dehydrogenase, Gre2, GRE2 gene product, Gre2p, isoamylaldehyde reductase, isopentanal reductase, isovaleral reductase, isovaleraldehyde reductase, More, protein YIM1, YIM1, YMR152W, Ymr152wp, YOL151W, YOL151w gene product

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.265 3-methylbutanal reductase

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Results	in table
2	Activating Compound
2	AA Sequence
1	Application
1	CAS Registry Number
3	Cloned(Commentary)
16	Cofactor
2	Crystallization (Commentary)
3	General Information
34	Inhibitors
11	kcat/KM [mM/s]
30	KM Value [mM]
5	Localization
2	Metals/Ions
1	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
12	Organism
6	PDB ID
3	pH Optimum
1	pH Stability
12	Protein Variants
2	Purification (Commentary)
1	Reaction
3	Reaction Type
12	Reference
6	Source Tissue
9	Specific Activity [micromol/min/mg]
50	Substrates and Products (Substrate)
1	Subunits
26	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
28	Turnover Number [1/s]

Crystallization

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Crystallization on EC 1.1.1.265 - 3-methylbutanal reductase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

crystal structures in an apo-form at 2.00 A and NADPH-complexed form at 2.40 A resolution. Gre2 forms a homodimer, each subunit of which contains an N-terminal Rossmann-fold domain and a variable C-terminal domain, which participates in substrate recognition. The induced fit upon binding to the cofactor NADPH makes the two domains shift toward each other, producing an interdomain cleft that better fits the substrate

Saccharomyces cerevisiae

Q12068

737753

in complex with NADP, to 3.2 A resolution. Monoclinic space group P21, two Gre2 protomers per asymmetric unit

Saccharomyces cerevisiae

Q12068

710768