1.1.1.25: shikimate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about shikimate dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

3-dehydroquinate dehydratase/shikimate dehydrogenase, 5-dehydroshikimate reductase, 5-dehydroshikimic reductase, ael1, Af2327, AroE, bifunctional dehydroquinate dehydratase-shikimate dehydrogenase, bifunctional DHQD-SDH/QDH, cgR_0495, cgR_1677, ChlreSDH, CsDQD/SDH, dehydroquinate dehydratase-shikimate dehydrogenase, dehydroquinate dehydratase/shikimate dehydrogenase, dehydroshikimic reductase, DHD/SHD, DHQ-SDH, DHQD-SDH, DHS reductase, DQD/SDH, EcDQD, EcDQD/SDH, EcDQD/SDH1, EcDQD/SDH2, EcDQD/SDH3, EcoSDH, EcSDH, EMB3004, HI0607, HpSDH, More, MtbSD, MtbSDH, NAD+-dependent enzyme quinate/shikimate dehydrogenase, NADP-dependent shikimate dehydrogenase, NADP-shikimate dehydrogenase, PgSDH, PhypaSDH, PintaSDH, Poptr1, Poptr5, PoptrSDH1, QDH/SDH, qsuD, quinate/shikimate dehydrogenase, RhobaSDH, rifI, SaSDH, SD, SDH, sdhL, SelmoSDH, ShDH, shikimate 5-dehydrogenase, shikimate dehydrogenase, shikimate oxidoreductase, shikimate:NADP oxidoreductase, shikimate:NADP+ 5-oxidoreductase, shikimate:NADP+ oxidoreductase, SKDH, TgSDH, tm0346, VvSDH1, VvSDH2, VvSDH3, VvSDH4, YdiB

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.25 shikimate dehydrogenase (NADP+)

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Results	in table
8	Activating Compound
42497	AA Sequence
27	Application
1	CAS Registry Number
54	Cloned(Commentary)
136	Cofactor
25	Crystallization (Commentary)
5	Expression
118	General Information
2	General Stability
17	IC50 Value
161	Inhibitors
86	kcat/KM [mM/s]
18	Ki Value [mM]
230	KM Value [mM]
9	Localization
3	Metals/Ions
37	Molecular Weight [Da]
98	Natural Substrates/ Products (Substrates)
521	Organism
6	Pathway
115	PDB ID
59	pH Optimum
9	pH Range
1	pH Stability
1	pI Value
65	Protein Variants
32	Purification (Commentary)
11	Reaction
4	Reaction Type
119	Reference
1	Renatured (Commentary)
47	Source Tissue
23	Specific Activity [micromol/min/mg]
7	Storage Stability
175	Substrates and Products (Substrate)
54	Subunits
220	Synonyms
1	Systematic Name
44	Temperature Optimum [°C]
3	Temperature Range [°C]
13	Temperature Stability [°C]
179	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.1.1.25 - shikimate dehydrogenase (NADP+)

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SYSTEMATIC NAME

IUBMB Comments

shikimate:NADP+ 3-oxidoreductase

NAD+ cannot replace NADP+ [3]. In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10, 3-dehydroquinate dehydratase [4]. cf. EC 1.1.1.24, quinate/shikimate dehydrogenase (NAD+), EC 1.1.5.8, quinate/shikimate dehydrogenase (quinone), and EC 1.1.1.282, quinate/shikimate dehydrogenase [NAD(P)+].