1.1.1.25: shikimate dehydrogenase (NADP+)

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For detailed information about shikimate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.1.1.25

1.1.1.25

3-dehydroshikimate

drug development

subdural

cinnamyl

dahps

5-enolpyruvylshikimate

pentafunctional

3-dehydroquinase

ammonialyase

analysis

diagnostics

food industry

agriculture

Reaction

Synonyms

3-dehydroquinate dehydratase/shikimate dehydrogenase, 5-dehydroshikimate reductase, 5-dehydroshikimic reductase, ael1, Af2327, AroE, bifunctional dehydroquinate dehydratase-shikimate dehydrogenase, bifunctional DHQD-SDH/QDH, cgR_0495, cgR_1677, ChlreSDH, CsDQD/SDH, dehydroquinate dehydratase-shikimate dehydrogenase, dehydroquinate dehydratase/shikimate dehydrogenase, dehydroshikimic reductase, DHD/SHD, DHQ-SDH, DHQD-SDH, DHS reductase, DQD/SDH, EcDQD, EcDQD/SDH, EcDQD/SDH1, EcDQD/SDH2, EcDQD/SDH3, EcoSDH, EcSDH, EMB3004, HI0607, HpSDH, More, MtbSD, MtbSDH, NAD+-dependent enzyme quinate/shikimate dehydrogenase, NADP-dependent shikimate dehydrogenase, NADP-shikimate dehydrogenase, PgSDH, PhypaSDH, PintaSDH, Poptr1, Poptr5, PoptrSDH1, QDH/SDH, qsuD, quinate/shikimate dehydrogenase, RhobaSDH, rifI, SaSDH, SD, SDH, sdhL, SelmoSDH, ShDH, shikimate 5-dehydrogenase, shikimate dehydrogenase, shikimate oxidoreductase, shikimate:NADP oxidoreductase, shikimate:NADP+ 5-oxidoreductase, shikimate:NADP+ oxidoreductase, SKDH, TgSDH, tm0346, VvSDH1, VvSDH2, VvSDH3, VvSDH4, YdiB

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.25 shikimate dehydrogenase (NADP+)

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Results	in table
8	Activating Compound
42497	AA Sequence
27	Application
1	CAS Registry Number
54	Cloned(Commentary)
136	Cofactor
25	Crystallization (Commentary)
5	Expression
118	General Information
2	General Stability
17	IC50 Value
161	Inhibitors
86	kcat/KM [mM/s]
18	Ki Value [mM]
230	KM Value [mM]
9	Localization
3	Metals/Ions
37	Molecular Weight [Da]
98	Natural Substrates/ Products (Substrates)
521	Organism
6	Pathway
115	PDB ID
59	pH Optimum
9	pH Range
1	pH Stability
1	pI Value
65	Protein Variants
32	Purification (Commentary)
11	Reaction
4	Reaction Type
119	Reference
1	Renatured (Commentary)
47	Source Tissue
23	Specific Activity [micromol/min/mg]
7	Storage Stability
175	Substrates and Products (Substrate)
54	Subunits
220	Synonyms
1	Systematic Name
44	Temperature Optimum [°C]
3	Temperature Range [°C]
13	Temperature Stability [°C]
179	Turnover Number [1/s]

Localization

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Localization on EC 1.1.1.25 - shikimate dehydrogenase (NADP+)

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additional information

Mycobacterium tuberculosis

the freeze-thaw method is able to yield the mutant protein in soluble form, after growth at 37°C for 24 h with IPTG induction of Escherichia coli C41 (DE3) cells harboring the recombinant plasmid. Best recombinant protein expression protocol of the K69A mutant in insoluble form is using Escherichia coli C41(DE3) strain, grown at 37°C for 24 h after induction with 1 mM IPTG, and cell disruption by sonication. Solubilization of recombinant wild-type and K69A enzymes in inclusion bodies is achieved by either treating the pellet with the denaturant agent urea (3 or 6 M) or by treating with the non ionic detergent zwittergent 3-14 (5%)

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