1.1.1.247: codeinone reductase (NADPH)
This is an abbreviated version!
For detailed information about codeinone reductase (NADPH), go to the full flat file.
Word Map on EC 1.1.1.247
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1.1.1.247
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morphine
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papaver
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poppy
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somniferum
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opium
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benzylisoquinoline
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morphinans
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narcotic
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thebaine
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berberine
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penultimate
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sanguinarine
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cyp80b1
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chalcone
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analgesics
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7-o-acetyltransferase
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s-n-methylcoclaurine
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laticifer
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3\'-hydroxylase
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bracteatum
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salutaridinol
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s-reticuline
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aldo-keto
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antitussive
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o-demethylase
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norcoclaurine
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6-o-methyltransferase
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4\'omt
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synthesis
- 1.1.1.247
- morphine
- papaver
- poppy
- somniferum
-
opium
-
benzylisoquinoline
-
morphinans
-
narcotic
- thebaine
- berberine
-
penultimate
- sanguinarine
- cyp80b1
- chalcone
-
analgesics
-
7-o-acetyltransferase
-
s-n-methylcoclaurine
-
laticifer
-
3\'-hydroxylase
- bracteatum
- salutaridinol
-
s-reticuline
-
aldo-keto
-
antitussive
- o-demethylase
- norcoclaurine
-
6-o-methyltransferase
-
4\'omt
- synthesis
Reaction
Synonyms
codeine oxidase, codeine: NADP oxidoreductase, codeine:NADP oxidoreductase, codeinone reductase, codeinone reductase (NADPH), CodR, COR, COR-B, COR1.1, COR1.2, COR1.3, COR1.4, PsCor1.1, reductase, codeinone (reduced nicotinamide adenine dinucleotide phosphate)
ECTree
1.1.1.247 codeinone reductase (NADPH)Advanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.1.1.247 - codeinone reductase (NADPH)
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
codeine + NADP+
codeinone + NADPH + H+
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r
morphine + NADP+
morphinone + NADPH + H+
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r
neomorphinone + NADPH + H+
neomorphine + NADP+
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ir
neopinone + NADPH + H+
neopine + NADP+
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ir
Codeinone + NADPH
Codeine + NADP+
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neopinone, which is formed most likely by demethylation of the vinylether of thebaine exists in the plant cell in a thermodynamic equilibrium with codeinone. The presence of the codeinone reductase/NADPH system shifts this equilibrium quantitatively in the direction of codeine, which either accumulates in the latex of the poppy plant or is further demethylated at the 3-OCH3 group yielding morphine
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?
Codeinone + NADPH
Codeine + NADP+
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important regulating function in morphine biosynthesis
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?
Codeinone + NADPH
Codeine + NADP+
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penultimate step in morphine biosynthesis
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r
additional information
?
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the enzyme is involved in biosynthesis of morphinan alkaloids, transcriptional regulation, overview
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?
additional information
?
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the enzyme is involved in the biosynthesis of morphine and the related antimicrobial alkaloid sanguinarine
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?
additional information
?
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the enzyme is involved in biosynthesis of morphinan alkaloids, overview
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?
additional information
?
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the enzyme also catalyzes the NADPH-dependent reduction of morphinone to morphine, reaction of EC 1.1.1.218. but codeine can also be directly converted into morphine, overview
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?
additional information
?
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the enzyme also catalyzes the NADPH-dependent reduction of morphinone to morphine, reaction of EC 1.1.1.218. but codeine can also be directly converted into morphine, overview
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?
additional information
?
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codeinone and morphinone are spontaneously converted to neopinone and neomorphinone, respectively. Latex protein extracts assayed for COR activity show the highest turnover of codeinone and morphinone to codeine and morphine, respectively. Codeine and morphine are also converted at reduced levels, whereas no conversion of either neopine or neomorphine is detected
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additional information
?
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codeinone and morphinone are spontaneously converted to neopinone and neomorphinone, respectively. Latex protein extracts assayed for COR activity show the highest turnover of codeinone and morphinone to codeine and morphine, respectively. Codeine and morphine are also converted at reduced levels, whereas no conversion of either neopine or neomorphine is detected
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additional information
?
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codeinone and morphinone are spontaneously converted to neopinone and neomorphinone, respectively. Latex protein extracts assayed for COR activity show the highest turnover of codeinone and morphinone to codeine and morphine, respectively. Codeine and morphine are also converted at reduced levels, whereas no conversion of either neopine or neomorphine is detected
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-
additional information
?
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codeinone and morphinone are spontaneously converted to neopinone and neomorphinone, respectively. Latex protein extracts assayed for COR activity show the highest turnover of codeinone and morphinone to codeine and morphine, respectively. Codeine and morphine are also converted at reduced levels, whereas no conversion of either neopine or neomorphine is detected
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-
additional information
?
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codeinone and morphinone are spontaneously converted to neopinone and neomorphinone, respectively. Latex protein extracts assayed for COR activity show the highest turnover of codeinone and morphinone to codeine and morphine, respectively. Codeine and morphine are also converted at reduced levels, whereas no conversion of either neopine or neomorphine is detected
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additional information
?
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codeinone and morphinone are spontaneously converted to neopinone and neomorphinone, respectively. Latex protein extracts assayed for COR activity show the highest turnover of codeinone and morphinone to codeine and morphine, respectively. Codeine and morphine are also converted at reduced levels, whereas no conversion of either neopine or neomorphine is detected
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