1.1.1.247: codeinone reductase (NADPH)
This is an abbreviated version!
For detailed information about codeinone reductase (NADPH), go to the full flat file.
Word Map on EC 1.1.1.247
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1.1.1.247
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morphine
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papaver
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poppy
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somniferum
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opium
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benzylisoquinoline
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morphinans
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narcotic
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thebaine
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berberine
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penultimate
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sanguinarine
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cyp80b1
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chalcone
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analgesics
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7-o-acetyltransferase
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s-n-methylcoclaurine
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laticifer
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3\'-hydroxylase
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bracteatum
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salutaridinol
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s-reticuline
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aldo-keto
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antitussive
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o-demethylase
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norcoclaurine
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6-o-methyltransferase
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4\'omt
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synthesis
- 1.1.1.247
- morphine
- papaver
- poppy
- somniferum
-
opium
-
benzylisoquinoline
-
morphinans
-
narcotic
- thebaine
- berberine
-
penultimate
- sanguinarine
- cyp80b1
- chalcone
-
analgesics
-
7-o-acetyltransferase
-
s-n-methylcoclaurine
-
laticifer
-
3\'-hydroxylase
- bracteatum
- salutaridinol
-
s-reticuline
-
aldo-keto
-
antitussive
- o-demethylase
- norcoclaurine
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6-o-methyltransferase
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4\'omt
- synthesis
Reaction
Synonyms
codeine oxidase, codeine: NADP oxidoreductase, codeine:NADP oxidoreductase, codeinone reductase, codeinone reductase (NADPH), CodR, COR, COR-B, COR1.1, COR1.2, COR1.3, COR1.4, PsCor1.1, reductase, codeinone (reduced nicotinamide adenine dinucleotide phosphate)
ECTree
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Engineering
Engineering on EC 1.1.1.247 - codeinone reductase (NADPH)
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A25V
site-directed mutagenesis, the mutant shows a marginal increase in neopine formation compared to wild-type
A25V/E111D/T145S/S165C
site-directed mutagenesis, the mutant shows a reduction in neopine formation compared to wild-type
E111D/T145S/S165C
site-directed mutagenesis, the mutant shows a reduction in neopine formation compared to wild-type
F129L
site-directed mutagenesis, the mutant of COR-B shows unaltered neopine formation compared to wild-type
K41N
site-directed mutagenesis, the mutant of COR-B shows unaltered neopine formation compared to wild-type
L129F
site-directed mutagenesis, the mutant shows a higher neopine yield compared to wild-type
N41K
site-directed mutagenesis, the mutant shows a higher neopine yield compared to wild-type
S279W
site-directed mutagenesis, the mutant shows a higher neopine yield compared to wild-type
V25A
site-directed mutagenesis, the mutant of COR-B shows 2fold reduced neopine formation compared to wild-type
W279S
site-directed mutagenesis, the mutant of COR-B shows 8fold reduced neopine formation compared to wild-type
additional information
the in vitro tetraploidy induction through methyl jasmonate (MeJA) elicitation causes a significantly increased expression of norcoclaurine synthase (NCS) and salutaridinol (SAT), and a significantly decreased expression of berberine bridge enzyme (BBE) in the leaves. In the root tissues, the BBE, NCS, and SAT show an increased expression in tetraploid plants, while codeinone reductase (COR) shows a decreased expression. A similar alteration pattern is found in mixoploid plants when compared to their diploid counterparts. MeJA at concentrations of 0.1 and 0.5 mM causes a remarkable increase in the thebaine content in the roots of treated plants, where the highest thebaine content is identified in plants elicited with 0.5 mM MeJA. Elicitation treatment causes a substantial increase in the expression of NCS and SAT in the leaves, while it has no major effect on BBE, codeine 3-O-demethylase (CODM) and COR. Expression analysis in the roots shows that MeJA causes a significant increase in the expression of only BBE and NCS, while expression of other studied genes remains unchanged
additional information
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the in vitro tetraploidy induction through methyl jasmonate (MeJA) elicitation causes a significantly increased expression of norcoclaurine synthase (NCS) and salutaridinol (SAT), and a significantly decreased expression of berberine bridge enzyme (BBE) in the leaves. In the root tissues, the BBE, NCS, and SAT show an increased expression in tetraploid plants, while codeinone reductase (COR) shows a decreased expression. A similar alteration pattern is found in mixoploid plants when compared to their diploid counterparts. MeJA at concentrations of 0.1 and 0.5 mM causes a remarkable increase in the thebaine content in the roots of treated plants, where the highest thebaine content is identified in plants elicited with 0.5 mM MeJA. Elicitation treatment causes a substantial increase in the expression of NCS and SAT in the leaves, while it has no major effect on BBE, codeine 3-O-demethylase (CODM) and COR. Expression analysis in the roots shows that MeJA causes a significant increase in the expression of only BBE and NCS, while expression of other studied genes remains unchanged
additional information
transgenic codeinone reductase overexpressing Papaver somniferum plants show 75% increase in thebaine besides 58% and 22% increases in codeine and morphine, respectively, compared to the wild-type plants in the field trail
additional information
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transgenic codeinone reductase overexpressing Papaver somniferum plants show 75% increase in thebaine besides 58% and 22% increases in codeine and morphine, respectively, compared to the wild-type plants in the field trail
additional information
combinations and permutations of the three substitutions N41K, L129F and S279W do not produce a synergistic effect
additional information
combinations and permutations of the three substitutions N41K, L129F and S279W do not produce a synergistic effect
additional information
combinations and permutations of the three substitutions N41K, L129F and S279W do not produce a synergistic effect
additional information
combinations and permutations of the three substitutions N41K, L129F and S279W do not produce a synergistic effect
additional information
combinations and permutations of the three substitutions N41K, L129F and S279W do not produce a synergistic effect
additional information
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combinations and permutations of the three substitutions N41K, L129F and S279W do not produce a synergistic effect
additional information
recombinant coexpression of isozyme COR-B with thebaine 6-O-demethylase (T6ODM) in Saccharomyces cerevisiae strain CEN.PK fed with thebaine, the strain expressing T6ODM and COR-B accumulates approximately 2fold more codeine and 10fold more neopine compared to wild-type
additional information
recombinant coexpression of isozyme COR-B with thebaine 6-O-demethylase (T6ODM) in Saccharomyces cerevisiae strain CEN.PK fed with thebaine, the strain expressing T6ODM and COR-B accumulates approximately 2fold more codeine and 10fold more neopine compared to wild-type
additional information
recombinant coexpression of isozyme COR-B with thebaine 6-O-demethylase (T6ODM) in Saccharomyces cerevisiae strain CEN.PK fed with thebaine, the strain expressing T6ODM and COR-B accumulates approximately 2fold more codeine and 10fold more neopine compared to wild-type
additional information
recombinant coexpression of isozyme COR-B with thebaine 6-O-demethylase (T6ODM) in Saccharomyces cerevisiae strain CEN.PK fed with thebaine, the strain expressing T6ODM and COR-B accumulates approximately 2fold more codeine and 10fold more neopine compared to wild-type
additional information
recombinant coexpression of isozyme COR-B with thebaine 6-O-demethylase (T6ODM) in Saccharomyces cerevisiae strain CEN.PK fed with thebaine, the strain expressing T6ODM and COR-B accumulates approximately 2fold more codeine and 10fold more neopine compared to wild-type
additional information
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recombinant coexpression of isozyme COR-B with thebaine 6-O-demethylase (T6ODM) in Saccharomyces cerevisiae strain CEN.PK fed with thebaine, the strain expressing T6ODM and COR-B accumulates approximately 2fold more codeine and 10fold more neopine compared to wild-type
additional information
recombinant coexpression of isozyme COR1.3 with thebaine 6-O-demethylase (T6ODM) in Saccharomyces cerevisiae strain CEN.PK fed with thebaine. In the recombinant strain, codeine and neopine accumulate to similar levels
additional information
recombinant coexpression of isozyme COR1.3 with thebaine 6-O-demethylase (T6ODM) in Saccharomyces cerevisiae strain CEN.PK fed with thebaine. In the recombinant strain, codeine and neopine accumulate to similar levels
additional information
recombinant coexpression of isozyme COR1.3 with thebaine 6-O-demethylase (T6ODM) in Saccharomyces cerevisiae strain CEN.PK fed with thebaine. In the recombinant strain, codeine and neopine accumulate to similar levels
additional information
recombinant coexpression of isozyme COR1.3 with thebaine 6-O-demethylase (T6ODM) in Saccharomyces cerevisiae strain CEN.PK fed with thebaine. In the recombinant strain, codeine and neopine accumulate to similar levels
additional information
recombinant coexpression of isozyme COR1.3 with thebaine 6-O-demethylase (T6ODM) in Saccharomyces cerevisiae strain CEN.PK fed with thebaine. In the recombinant strain, codeine and neopine accumulate to similar levels
additional information
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recombinant coexpression of isozyme COR1.3 with thebaine 6-O-demethylase (T6ODM) in Saccharomyces cerevisiae strain CEN.PK fed with thebaine. In the recombinant strain, codeine and neopine accumulate to similar levels
additional information
the COR1.4 single-substitution mutant A (A25V) results in a marginal increase in neopine formation, whereas the triple C (E111D), E (T145S) and F (S165C), and the quadruple A (A25V), C (E111D), E (T145S) and F (S165C), mutants result in higher reductions in neopine levels
additional information
the COR1.4 single-substitution mutant A (A25V) results in a marginal increase in neopine formation, whereas the triple C (E111D), E (T145S) and F (S165C), and the quadruple A (A25V), C (E111D), E (T145S) and F (S165C), mutants result in higher reductions in neopine levels
additional information
the COR1.4 single-substitution mutant A (A25V) results in a marginal increase in neopine formation, whereas the triple C (E111D), E (T145S) and F (S165C), and the quadruple A (A25V), C (E111D), E (T145S) and F (S165C), mutants result in higher reductions in neopine levels
additional information
the COR1.4 single-substitution mutant A (A25V) results in a marginal increase in neopine formation, whereas the triple C (E111D), E (T145S) and F (S165C), and the quadruple A (A25V), C (E111D), E (T145S) and F (S165C), mutants result in higher reductions in neopine levels
additional information
the COR1.4 single-substitution mutant A (A25V) results in a marginal increase in neopine formation, whereas the triple C (E111D), E (T145S) and F (S165C), and the quadruple A (A25V), C (E111D), E (T145S) and F (S165C), mutants result in higher reductions in neopine levels
additional information
-
the COR1.4 single-substitution mutant A (A25V) results in a marginal increase in neopine formation, whereas the triple C (E111D), E (T145S) and F (S165C), and the quadruple A (A25V), C (E111D), E (T145S) and F (S165C), mutants result in higher reductions in neopine levels