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10-oxonortriptyline + NADPH
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a drug acting as substrate
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17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H + H+
3alpha,17beta-dihydroxy-5alpha-androstan + NAD(P)+
2 tibolone + 2 NADPH + 2 H+
3alpha-hydroxytibolone + 3beta-hydroxytibolone + 2 NADP+
i.e. tibolone, a 3-ketosteroid androgen receptor, conversion to potent estrogen receptor alpha agonists, tibolone induces estrogen receptor alpha-dependent gene promoter activity through cis-acting estrogen response elements, increases the stimulatory effect of TGF-beta on Smad-dependent gene promoter activity, and enhances prostaglandin E2-induced activity of transcription factor Runx2, overview
3alpha-hydroxytibolone is the primary metabolite
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3-ketosteroids + NADPH
3-hydroxysteroids + NADP+
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3alpha,5alpha-allopregnenolone + NAD(P)+
5alpha-dihydroprogesterone + NAD(P)H
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i.e. 3alpha,5alpha-tetrahydroprogesterone or 3alpha,5alpha-THP, the enzyme catalyzes the biosynthesis and oxidation of 3alpha,5alpha-reduced neurosteroids as allopregnanolone, which stimulates GABAA receptors, sciatic nerves-induced analgesia results in increased enzyme levels in neuropathic rats, overview
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3alpha-androstanediol + NAD+
5alpha-dihydrotestosterone + NADH + H+
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steroid reduction direction is preferred
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4-acetylpyridine + NADPH + H+
(S)-1-(4-pyridyl)ethanol + NADP+
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5alpha-dihydrotestosterone + NAD(P)H + H+
5alpha-androstane-3alpha,17beta-diol + NAD(P)+
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5alpha-dihydrotestosterone + NADPH
5alpha-androstane-3alpha,17beta-diol + NADP+
5alpha-dihydrotestosterone + NADPH + H+
3alpha-androstanediol + NADP+
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steroid reduction direction is preferred
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5alpha-dihydrotestosterone + NADPH + H+
5alpha-androstan-3alpha,17beta-diol + NADP+
5alpha-pregnan-3,20-dione + NAD(P)H + H+
5alpha-pregnan-3alpha-ol-20-one + NAD(P)+
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regulation of the amount of allosteric agonists that can bind to the GABA receptor in brain
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5beta-pregnane-17alpha,20beta,21-triol-3,11-dione + NAD(P)H
5beta-pregnane-3alpha,17alpha,20beta,21-tetraol-11-one + NAD(P)+
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hepatic reduction in animal tissues
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9-(phenylcarbonyl)-2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11-one + NADPH
9-[hydroxy(phenyl)methyl]-2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11-one + NADP+
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competitive substrate, fluorometric activity measurement in intact cells, overview
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acetohexamide + NADPH
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a drug acting as substrate
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acetophenone + NADPH + H+
1-phenylethanol + NADP+
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androsterone + NAD+
5alpha-androstane-3,17-dione + NADH
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androsterone + NAD+
androstanedione + NADH
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androsterone + NADP+
5alpha-androstane-3,17-dione + NADPH
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befunolol + NADPH
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a drug acting as substrate
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daunorubicin + NADPH
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a drug acting as substrate
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dolasetron + NADPH
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a drug acting as substrate
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haloperidol + NADPH
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a drug acting as substrate
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ketoprofen + NADPH
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a drug acting as substrate
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ketotifen + NADPH
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a drug acting as substrate
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loxoprofen + NADPH
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a drug acting as substrate
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Naloxone + NADPH
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a drug acting as substrate
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Naltrexone + NADPH
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a drug acting as substrate
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oracin + NADPH
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a drug acting as substrate
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oxycodone + NADPH
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a drug acting as substrate
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tibolone + NADPH + H+
3-hydroxytibolone + NADP+
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tibolone is used to treat climacteric symptoms and prevent osteoporosis, it exerts tissue-selective effects via site-specific metabolism into 3alpha- and 3beta-hydroxymetabolites and a DELTA4-isomer
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additional information
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17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H + H+
3alpha,17beta-dihydroxy-5alpha-androstan + NAD(P)+
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17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H + H+
3alpha,17beta-dihydroxy-5alpha-androstan + NAD(P)+
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17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H + H+
3alpha,17beta-dihydroxy-5alpha-androstan + NAD(P)+
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termination of androgen action
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17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H + H+
3alpha,17beta-dihydroxy-5alpha-androstan + NAD(P)+
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conversion in animal tissues
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17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H + H+
3alpha,17beta-dihydroxy-5alpha-androstan + NAD(P)+
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regulation of the amount of androgen in prostate, high levels of substrate are required for normal and abnormal growth of prostate
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17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H + H+
3alpha,17beta-dihydroxy-5alpha-androstan + NAD(P)+
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termination of androgen action
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5alpha-dihydrotestosterone + NADPH
5alpha-androstane-3alpha,17beta-diol + NADP+
androgen-inactivating enzyme
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5alpha-dihydrotestosterone + NADPH
5alpha-androstane-3alpha,17beta-diol + NADP+
the enzyme is important in inactivation of DHT
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5alpha-dihydrotestosterone + NADPH
5alpha-androstane-3alpha,17beta-diol + NADP+
the enzyme plays a crucial role in the regulation of the intracellular concentrations of testosterone and 5alpha-dihydrotestosterone, two steroids directly linked to the etiology and the progression of many prostate diseases and cancer, overview
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5alpha-dihydrotestosterone + NADPH
5alpha-androstane-3alpha,17beta-diol + NADP+
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5alpha-dihydrotestosterone + NADPH + H+
5alpha-androstan-3alpha,17beta-diol + NADP+
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inactivation of the potent androgen in human prostate
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5alpha-dihydrotestosterone + NADPH + H+
5alpha-androstan-3alpha,17beta-diol + NADP+
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inactivation of the potent androgen in human prostate, fluorometric activity measurement in intact cells, overview
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additional information
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the enzyme is important in the synthesis of neuroactive 5alpha/beta-pregnan-3alpha-ol-20-ones from their precursors, the enzyme plays a role in development and progression of prostate cancer
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additional information
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the enzyme is important in the synthesis of neuroactive 5alpha/beta-pregnan-3alpha-ol-20-ones from their precursors, the enzyme plays a role in development and progression of prostate cancer
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additional information
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the RODH like 3alpha/17beta-HSD, EC 1.1.1.239, regulates the transactivation of AKR1C2, overview
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additional information
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the RODH like 3alpha/17beta-HSD, EC 1.1.1.239, regulates the transactivation of AKR1C2, overview
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additional information
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AKR1C3 catalyzes androgen, estrogen, and prostaglandin metabolism, AKR1C3 is also involved in cancer development or progression
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additional information
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an androgen-inactivating enzyme, important in androgen and progesterone metabolism
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additional information
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biosynthesis and inactivation of steroid hormones, physiological role is to inactivate circulating androgens, progestins and glucocorticoids
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additional information
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involved in biosynthesis of bile acids
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additional information
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inactivating circulating androgens, progestins and glucocorticoids. Regulation of hormone levels in endocrine target tissues and in carcinogen actibation
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additional information
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AKR1C9 catalyzes androgen, estrogen, and prostaglandin metabolism
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additional information
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C/EBPdelta regulates the AKR1C9 gene promoter in osteoblasts, overview
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additional information
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involved in biosynthesis of bile acids
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