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0.0027
(5beta,20R)-20-hydroxypregnan-3-one
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.0012 - 0.726
17beta-hydroxy-5alpha-androstan-3-one
3.54 - 33.7
2-decalone
-
-
0.179
3-oxo-deoxycholic acid
coenzyme: NADPH, pH 7.0, temperature not specified in the publication
-
0.0031
3alpha-androstanediol
-
pH 7.0, 25°C, recombinant enzyme
0.0013 - 0.408
3alpha-hydroxy-5alpha-androstan-17-one
0.163 - 0.211
4-nitrobenzaldehyde
-
-
0.0031
4-oxo-2-nonenal
pH 7.4, 25°C
0.0011 - 0.0304
5alpha-androstan-3,17-dione
0.00008 - 0.00065
5alpha-androstane-3,17-dione
0.781 - 7.331
5alpha-androstane-3alpha,17beta-diol
0.0013 - 0.012
5alpha-dihydrotestosterone
0.0021
5beta-androstane-3,17-dione
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.01
5beta-pregnane-17alpha,20beta,21-triol-3,11-dione
-
-
0.0024
5beta-pregnane-3,20-dione
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.023
6-tert-butyl-2,3-epoxy-4-hydroxy-5-cyclohexen-1-one
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.00122 - 0.038
9,10-phenanthrenequinone
0.003
9-(phenylcarbonyl)-2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11-one
-
recombinant enzyme in intact COS-1 cells
0.00044 - 0.1
androsterone
0.004
Dehydrolithocholic acid
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.155
deoxycholic acid
coenzyme: NADP+, pH 10, temperature not specified in the publication
0.42
diacetyl
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.022
isatin
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
additional information
(11S,12S)-11,12-dihydrobenzo[g]chrysene-11,12-diol
0.0012
17beta-hydroxy-5alpha-androstan-3-one
-
cloned human liver enzyme type I
0.0192
17beta-hydroxy-5alpha-androstan-3-one
-
cloned human liver enzyme type II
0.505
17beta-hydroxy-5alpha-androstan-3-one
-
NAD(H), prostate
0.614
17beta-hydroxy-5alpha-androstan-3-one
-
NADP(H), prostate
0.645
17beta-hydroxy-5alpha-androstan-3-one
-
NADP(H), epididymis
0.726
17beta-hydroxy-5alpha-androstan-3-one
-
NAD(H), epididymis
0.0013 - 0.0441
3alpha-hydroxy-5alpha-androstan-17-one
NAD+
0.0041 - 0.024
3alpha-hydroxy-5alpha-androstan-17-one
NADP+
0.0094
3alpha-hydroxy-5alpha-androstan-17-one
-
-
0.029
3alpha-hydroxy-5alpha-androstan-17-one
-
Y205F
0.042 - 0.408
3alpha-hydroxy-5alpha-androstan-17-one
-
-
0.046
3alpha-hydroxy-5alpha-androstan-17-one
-
recombinant wild type enzyme
0.047
3alpha-hydroxy-5alpha-androstan-17-one
-
-
0.0011 - 0.0039
5alpha-androstan-3,17-dione
NADPH
0.0017
5alpha-androstan-3,17-dione
-
-
0.0039 - 0.0304
5alpha-androstan-3,17-dione
NADH
0.0041
5alpha-androstan-3,17-dione
-
recombinant wild type enzyme
0.0042
5alpha-androstan-3,17-dione
-
Y205F
0.00008
5alpha-androstane-3,17-dione
-
-
0.00065
5alpha-androstane-3,17-dione
-
pH 7.0, 25, reduction reaction
0.781
5alpha-androstane-3alpha,17beta-diol
-
NAD(H), prostate
1.09
5alpha-androstane-3alpha,17beta-diol
-
NADP(H), prostate
3.042
5alpha-androstane-3alpha,17beta-diol
-
NAD(H), epididymis
7.331
5alpha-androstane-3alpha,17beta-diol
-
NADP(H), epididymis
0.0013
5alpha-dihydrotestosterone
-
recombinant enzyme in intact COS-1 cells
0.0029
5alpha-dihydrotestosterone
-
pH 7.0, 25°C, recombinant enzyme
0.0057
5alpha-dihydrotestosterone
pH 7.5, recombinant wild-type enzyme
0.0059
5alpha-dihydrotestosterone
pH 7.5, recombinant mutant R301L
0.012
5alpha-dihydrotestosterone
pH 7.5, recombinant mutant R304L
0.00122 - 0.0051
9,10-phenanthrenequinone
-
-
0.038
9,10-phenanthrenequinone
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.00044
androsterone
-
pH 9.0, 25°C, recombinant mutant S114A/Y155F
0.0041
androsterone
-
pH 7.0, 25, oxidation reaction
0.0051
androsterone
-
pH 10.4, 25°C, recombinant wild-type enzyme
0.0055
androsterone
-
pH 9.0, 25°C, recombinant wild-type enzyme
0.007
androsterone
-
pH 9.0, 25°C, recombinant mutant S114A
0.033
androsterone
-
pH 10.4, 25°C, recombinant mutant K159A
0.065
androsterone
-
pH 9.0, 25°C, recombinant mutant K159A
0.074
androsterone
-
pH 9.0, 25°C, recombinant mutant Y155F
0.1
androsterone
-
pH 9.0, 25°C, recombinant mutant Y155F/K159A
0.004 - 0.821
NAD+
-
0.94
NAD+
-
recombinant wild type enzyme
0.0057 - 0.0312
NADH
-
0.027
NADH
-
recombinant wild type enzyme
0.0026
NADP+
-
-
0.00016
NADPH
-
-
additional information
(11S,12S)-11,12-dihydrobenzo[g]chrysene-11,12-diol
racemic benzo[g]chrysene-11,12-dihydrodiol derived from the fjord-region parent hydrocarbon benzo[g]chrysene is oxidized with a kcat/Km of 1520 min/mM, which is more than 100 times greater than that observed with benzo[a]pyrene-7,8-dihydrodiol
additional information
benzo[a]pyrene-7,8-dihydrodiol
kcat/Km of 39 min/mM
additional information
additional information
-
kinetics
-
additional information
additional information
-
steady-state kinetics
-
additional information
additional information
-
transient-state and steady-state kinetics
-
additional information
additional information
-
equilibrium kinetics of wild-type and mutant enzymes
-
additional information
additional information
-
stereoselectivity, kinetics
-
additional information
additional information
-
transient single and multiple turnover kinetics, stopped flow kinetics, isotope kinetics, ligand binding analysis, kinetics with deuterium-substituted cofactor and binary complex of enzyme and cofactor, overview
-
additional information
additional information
-
cofactor kinetics of wild-type and mutant enzymes, overview
-
additional information
additional information
-
kinetics in absence and presence of co-solvents, overview
-
additional information
additional information
-
kinetics of wild-type and mutant enzymes in presence or absence of CAPS and methylamine, overview
-
additional information
additional information
-
steady-state, transient state kinetics, and kinetic isotope effects, kinetic analysis and mechanism, ordered bi-bi mechanism, detailed overview
-