Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.1.1.21: aldose reductase

This is an abbreviated version!
For detailed information about aldose reductase, go to the full flat file.

Word Map on EC 1.1.1.21

Reaction

alditol
+
NAD(P)+
=
aldose
+
NAD(P)H
+
H+

Synonyms

17betaHSD5, 20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, AdhA, AKR1B, AKR1B1, AKR1B10, AKR1B13, AKR1B14, AKR1B3, AKR1C3, AKR4C7, aldehyde reductase, alditol/NADP+ oxidoreductase, alditol: NADP+ 1-oxidoreductase, alditol:NAD(P)+1oxidoreductase, alditol:NADP 1-oxidoreductase, alditol:NADP oxidoreductase, aldo-keto reductase, aldo-keto reductase family 1 member B1, aldo-keto reductase family 1 member B7, aldoketo reductase 1C3, aldose reductase, aldose reductase 2, aldose reductase-like, aldose reductase-like protein, aldose xylose reductase, ALDRXV4, ALR, ALR1, ALR2, AR, ARI, BAR, EC 1.1.1.139, Fibroblast growth factor regulated protein, FR-1 protein, GRE3, HAR, HRAR, isobutyraldehyde reductase, More, MVDP, NADPH dependent xylose reductase, NADPH-aldopentose reductase, NADPH-aldose reductase, polyol dehydrogenase (NADP2), RLAR, small intestine reductase, TPN-polyol dehydrogenase, VAS deferens androgen-dependent protein, YqhD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.21 aldose reductase

Substrates Products

Substrates Products on EC 1.1.1.21 - aldose reductase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(1S)-camphorquinone + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
(3R,4S/3S,4R)-3,4-(cis)acetate-beta-lactam + NADPH + H+
4-hydroxyazetidine-2,3-diyl diacetate + NADP+
show the reaction diagram
-
screening of 19 individual yeast reductases for their effciency and enantioselectivity, overview
stereochemistry of products of the different enzymes, detailed overview
-
?
(S)-1-indanol + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
(S)-1-tetralol + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
1-butanal + NADPH + H+
1-butanol + NADP+
show the reaction diagram
-
-
-
-
?
1-butanal + NADPH + H+
butanol + NADP+
show the reaction diagram
-
-
-
?
1-decanal + NADPH + H+
1-decanol + NADP+
show the reaction diagram
-
-
-
-
?
1-decanol + NADP+
decanal + NADPH + H+
show the reaction diagram
-
-
-
?
1-dodecanal + NADPH + H+
dodecanol + NADP+
show the reaction diagram
-
-
-
?
1-heptanal + NADPH + H+
heptanol + NADP+
show the reaction diagram
-
-
-
?
1-hexanal + NADPH + H+
1-hexanol + NADP+
show the reaction diagram
-
-
-
-
?
1-hexanal + NADPH + H+
hexanol + NADP+
show the reaction diagram
-
-
-
?
1-hydroxynonen-4-one + NADPH
1,4-dihydroxynon-2-ene + NADP+
show the reaction diagram
-
-
-
?
1-nonanal + NADPH + H+
1-nonanol + NADP+
show the reaction diagram
-
-
-
-
?
1-nonanal + NADPH + H+
nonanol + NADP+
show the reaction diagram
-
-
-
?
1-nonanol + NADP+
nonanal + NADPH + H+
show the reaction diagram
-
-
-
?
1-palmitoyl-2-(5-oxovaleryl)sn-glycero-3-phosphocholine + NADPH
1-palmitoyl-2-(5-hydroxyvaleryl)sn-glycero-3-phosphocholine + NADP+
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-(5-oxovaleryl)sn-glycero-3-phosphocholine + NADPH + H+
? + NADP+
show the reaction diagram
ALR2
-
-
?
1-propanal + NADPH + H+
1-propanol + NADP+
show the reaction diagram
-
-
-
-
?
1-tetradecanol + NADP+
tetradecanal + NADPH + H+
show the reaction diagram
-
-
-
?
11-deoxyisocorticosterone + NAD(P)H
?
show the reaction diagram
-
-
-
-
?
16-ketoestrone + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2,3-bornanedione + NAD(P)H
?
show the reaction diagram
-
-
-
-
?
2,3-butanedione + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2,3-heptanedione + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2,3-hexanedione + NADPH + H+
?
show the reaction diagram
2,3-pentanedione + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2,4-decadienal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2,4-nonadienal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2-D-deoxy-2-fluoro-galactose + NADPH
?
show the reaction diagram
-
-
-
-
r
2-D-deoxygalactose + NADPH
?
show the reaction diagram
2-decenal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2-deoxy-2-fluoro-galactose + NADPH + H+
?
show the reaction diagram
-
-
-
-
r
2-deoxyribose + NADPH
?
show the reaction diagram
-
-
-
-
r
2-hexenal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2-nonenal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
2-phenyl-2-propenal + NADPH + H+
2-phenyl-1-propanol + NADP+
show the reaction diagram
-
-
-
-
?
20-isocortisol + NAD(P)H
?
show the reaction diagram
-
-
-
-
?
20alpha-hydroxyprogesterone + NADPH + H+
?
show the reaction diagram
-
-
-
?
20alpha-isocorticosterone + NAD(P)H
?
show the reaction diagram
-
-
-
-
?
21-dehydrocortisol + NADPH + H+
?
show the reaction diagram
3,4-hexanedione + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
3-deoxyglucosone + NADPH + H+
?
show the reaction diagram
3-glutathionyl-4-hydroxynonanal + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
3-nitrobenzaldehyde + NADPH + H+
3-nitrobenzyl alcohol + NADP+
show the reaction diagram
-
-
-
?
3-pyridinecarboxaldehyde + NADPH + H+
3-pyridinemethanol + NADP+
show the reaction diagram
-
-
-
-
r
4-bromobenzaldehyde + NADPH + H+
4-bromobenzyl alcohol + NADP+
show the reaction diagram
-
-
-
-
r
4-carboxybenzaldehyde + NADPH + H+
4-carboxybenzyl alcohol + NADP+
show the reaction diagram
-
-
-
-
r
4-hydroxy-trans-2-nonenal + NADPH + H+
1,4-dihydroxynonane + NADP+
show the reaction diagram
-
-
-
-
?
4-hydroxynonenal + NADPH + H+
4-hydroxynonanol + NADP+
show the reaction diagram
4-hydroxynonenal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
4-hydroxyphenylacetaldehyde + NAD(P)H
4-hydroxyphenylethyl alcohol + NAD(P)+
show the reaction diagram
-
-
-
-
?
4-hydroxyphenylglycolaldehyde + NAD(P)H
?
show the reaction diagram
-
-
-
-
?
4-nitrobenzaldehyde + NAD(P)H
4-nitrobenzyl alcohol + NAD(P)+
show the reaction diagram
4-nitrobenzaldehyde + NADPH + H+
4-nitrobenzyl alcohol + NADP+
show the reaction diagram
4-nitrobenzaldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
?
4-oxonon-2-enal + NADPH + H+
1-hydroxynonen-4-one + NADP+
show the reaction diagram
-
-
-
?
4-pyridinecarboxaldehyde + NADPH + H+
4-pyridinemethanol + NADP+
show the reaction diagram
-
-
-
-
r
5-pregnene-3beta,20alpha-diol + NADPH
?
show the reaction diagram
-
-
-
?
5alpha-pregnan-20alpha-ol-3-one + NADPH + H+
?
show the reaction diagram
-
-
-
?
5alpha-pregnane-3beta,20alpha-diol + NADPH + H+
?
show the reaction diagram
-
-
-
?
8-acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-aza-benzo[de]anthracen-10-one + NADPH + H+
? + NADP+
show the reaction diagram
fluorogenic synthetic substrate
-
-
?
acetaldehyde + NAD(P)H + H+
ethanol + NAD(P)+
show the reaction diagram
acetaldehyde + NADPH + H+
ethanol + NADP+
show the reaction diagram
acetol + NADPH
propane-1,2 diol + NADP+
show the reaction diagram
-
-
-
-
?
acrolein + NADPH
2-propen-1-ol + NADP+
show the reaction diagram
-
-
-
-
?
acrolein + NADPH + H+
2-propen-1-ol + NADP+
show the reaction diagram
-
-
-
-
?
alditol + NAD(P)+
aldose + NAD(P)H
show the reaction diagram
aldose + NAD(P)H
alditol + NAD(P)+
show the reaction diagram
aldose + NADPH + H+
alditol + NADP+
show the reaction diagram
benzaldehyde + NAD(P)H
benzyl alcohol + NAD(P)+
show the reaction diagram
benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
show the reaction diagram
benzyl alcohol + oxidized 3-acetylpyridine adenine dinucleotide + H+
benzaldehyde + reduced 3-acetylpyridine adenine dinucleotide
show the reaction diagram
butyraldehyde + NAD(P)H
butanol + NAD(P)+
show the reaction diagram
D-arabinose + NADPH
arabitol + NADP+
show the reaction diagram
-
-
-
-
r
D-arabinose + NADPH + H+
arabitol + NADP+
show the reaction diagram
D-erythrose + NAD(P)H
erythritol + NAD(P)+
show the reaction diagram
D-erythrose + NADPH + H+
?
show the reaction diagram
D-fructose + NAD(P)H + H+
D-arabino-hexitol + NAD(P)+
show the reaction diagram
D-fucose + NADPH
fucitol + NADP+
show the reaction diagram
-
-
-
-
r
D-galactose + NAD(P)H
dulcitol + NAD(P)+
show the reaction diagram
D-galactose + NADPH
?
show the reaction diagram
D-galactose + NADPH + H+
?
show the reaction diagram
D-galactose + NADPH + H+
D-galactitol + NADP+
show the reaction diagram
D-glucose + NAD(P)H
sorbitol + NAD(P)+
show the reaction diagram
D-glucose + NADPH + H+
D-sorbitol + NADP+
show the reaction diagram
D-glucose + NADPH + H+
sorbitol + NADP+
show the reaction diagram
D-glucose 6-phosphate + NADPH + H+
?
show the reaction diagram
-
-
-
-
r
D-glucuronate + NAD(P)H
?
show the reaction diagram
D-glucuronate + NADPH
?
show the reaction diagram
-
-
-
-
?
D-glucuronate + NADPH
? + NADP+
show the reaction diagram
D-glucuronolactone + NADPH
?
show the reaction diagram
D-glyceraldehyde + NAD(P)H
glycerol + NAD(P)+
show the reaction diagram
D-glyceraldehyde + NAD(P)H + H+
glycerol + NAD(P)+
show the reaction diagram
-
-
-
-
?
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
D-lactaldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
?
D-lactoaldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
D-lyxose + NADPH
arabitol + NADP+
show the reaction diagram
D-mannose + NAD(P)H
mannitol + NAD(P)+
show the reaction diagram
D-ribose + NAD(P)H
ribitol + NAD(P)+
show the reaction diagram
D-ribose + NADPH
adonitol + NADP+
show the reaction diagram
-
-
-
-
r
D-ribose + NADPH + H+
?
show the reaction diagram
D-ribose + NADPH + H+
adonitol + NADP+
show the reaction diagram
-
-
-
?
D-ribose + NADPH + H+
D-ribitol + NADP+
show the reaction diagram
-
-
-
?
D-ribose 5-phosphate + NADPH
D-ribitol 5-phosphate + NADP+
show the reaction diagram
-
-
-
-
r
D-tagatose + NADPH
?
show the reaction diagram
-
-
-
-
r
D-xylose + NAD(P)H
xylitol + NAD(P)+
show the reaction diagram
D-xylose + NADPH
?
show the reaction diagram
-
-
-
-
?
D-xylose + NADPH
xylitol + NADP+
show the reaction diagram
D-xylose + NADPH + H+
?
show the reaction diagram
D-xylose + NADPH + H+
D-xylitol + NADP+
show the reaction diagram
D-xylose + NADPH + H+
xylitol + NADP+
show the reaction diagram
-
-
-
?
D-xylose 5-phosphate + NADPH
D-xylitol 5-phosphate + NADP+
show the reaction diagram
-
-
-
-
r
D-xylulose + NADPH + H+
D-xylitol + NADP+
show the reaction diagram
-
-
-
-
?
decanal + NAD(P)H
decanol + NAD(P)+
show the reaction diagram
-
-
-
-
?
dihydroxyacetone + NAD(P)H
glycerol + NAD(P)+
show the reaction diagram
-
-
-
-
?
DL-glyceraldehyde + NAD(P)H
glycerol + NAD(P)+
show the reaction diagram
DL-glyceraldehyde + NAD(P)H + H+
glycerol + NAD(P)+
show the reaction diagram
-
-
-
?
DL-glyceraldehyde + NADPH
glycerol + NAD(P)+
show the reaction diagram
-
-
-
-
?
DL-glyceraldehyde + NADPH
glycerol + NADP+
show the reaction diagram
DL-glyceraldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
?
DL-glyceraldehyde + NADPH + H+
DL-glycerol + NADP+
show the reaction diagram
DL-glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
farnesal + NADPH + H+
trans,trans-farnesol + NADP+
show the reaction diagram
specific substrate
-
-
?
geraniol + NADP+
geranial + NADPH + H+
show the reaction diagram
-
-
-
?
geranylgeranial + NADPH + H+
geranylgeraniol + NADP+
show the reaction diagram
specific substrate
-
-
?
glucose + NADPH
sorbitol + NADP+
show the reaction diagram
glutathione-4-hydroxy-trans-2-nonenal + NADPH + H+
glutathione-1,4-dihydroxynonane + NADP+
show the reaction diagram
-
-
-
-
?
glutathione-S-4-oxonon-2-enal + NADPH
S-(1-hydroxy-4-oxonona-3-yl)glutathione + NADP+
show the reaction diagram
-
-
-
?
glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
glycoaldehyde + NADPH
ethylene glycol + NADP+
show the reaction diagram
-
-
-
-
?
glycoaldehyde + NADPH + H+
ethylene glycol + NADP+
show the reaction diagram
-
-
-
-
?
glycolaldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
?
glyoxal + NADPH
?
show the reaction diagram
-
-
-
-
?
glyoxal + NADPH + H+
?
show the reaction diagram
hexanal + NADPH + H+
hexanol + NADP+
show the reaction diagram
indole-3-acetaldehyde + NAD(P)H
indole-3-ethanol + NAD(P)+
show the reaction diagram
-
-
-
-
?
isatin + NADPH + H+
3-hydroxyisatin + NADP+
show the reaction diagram
specific substrate
-
-
?
isatin + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
isobutyraldehyde + NADPH + H+
isobutanol + NADP+
show the reaction diagram
isocaproaldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
?
isophthalaldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
?
L-arabinose + NAD(P)H
L-arabitol + NAD(P)+
show the reaction diagram
L-arabinose + NADPH
arabitol + NADP+
show the reaction diagram
-
-
-
-
r
L-fucose + NADPH
fucitol + NADP+
show the reaction diagram
-
-
-
-
r
L-glyceraldehyde + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
L-glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
-
-
-
-
r
L-idose + NADPH + H+
alditol + NADP+
show the reaction diagram
L-lyxose + NADPH
arabitol + NADP+
show the reaction diagram
-
-
-
-
r
L-rhamnose + NADPH
L-rhamnitol + NADP+
show the reaction diagram
-
-
-
-
r
L-ribose + NADPH
adonitol + NADP+
show the reaction diagram
-
-
-
-
r
L-sorbose + NADPH + H+
L-sorbitol + NADP+
show the reaction diagram
-
-
-
-
r
L-threose + NADPH + H+
?
show the reaction diagram
L-xylose + NAD(P)H
L-xylitol + NAD(P)+
show the reaction diagram
L-xylose + NADP+
xylitol + NADPH + H+
show the reaction diagram
-
-
-
-
?
malondialdehyde + NADPH + H+
?
show the reaction diagram
-
-
-
?
methylglyoxal + NADPH
?
show the reaction diagram
methylglyoxal + NADPH + H+
?
show the reaction diagram
methylglyoxal + NADPH + H+
acetol + NADP+
show the reaction diagram
-
-
-
-
?
n-pentanal + NAD(P)H + H+
n-pentanol + NAD(P)+
show the reaction diagram
nerol + NADPH + H+
?
show the reaction diagram
-
-
-
?
octanal + NADPH + H+
1-octanol + NADP+
show the reaction diagram
-
-
-
-
?
octanal + NADPH + H+
octanol + NADP+
show the reaction diagram
-
-
-
?
pentose + NADPH
pentitol + NADP+
show the reaction diagram
pentose + NADPH + H+
pentiol + NADP+
show the reaction diagram
phenyl-1,2-propanedione + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
phenylglyoxal + NAD(P)H
?
show the reaction diagram
phenylglyoxal + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
propanal + NADPH + H+
n-propanol + NADP+
show the reaction diagram
-
-
-
-
r
propionaldehyde + NAD(P)H
propanol + NAD(P)+
show the reaction diagram
pyridine-3-aldehyde + NAD(P)H
3-hydroxypyridine + NAD(P)+
show the reaction diagram
pyridine-3-aldehyde + NADPH + H+
3-pyridinemethanol + NADP+
show the reaction diagram
pyridine-3-methanol + NADP+
?
show the reaction diagram
-
-
-
?
pyridine-3-methanol + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
pyridine-4-aldehyde + NAD(P)H
4-hydroxypyridine + NAD(P)+
show the reaction diagram
-
-
-
-
r
pyridine-4-aldehyde + NADPH + H+
4-hydroxypyridine + NADP+
show the reaction diagram
-
-
-
-
?
pyridinecarboxaldehyde + NAD(P)H
pyridylmethanol + NAD(P)+
show the reaction diagram
sorbitol + NAD+
D-fructose + NADH + H+
show the reaction diagram
succinic semialdehyde + NADH + H+
4-hydroxybutyrate + NAD+
show the reaction diagram
trans-2-buten-1-al + NADPH + H+
?
show the reaction diagram
-
-
-
?
trans-2-decen-1-al + NADPH + H+
?
show the reaction diagram
-
-
-
?
trans-2-hexen-1-al + NADPH + H+
?
show the reaction diagram
-
-
-
?
trans-2-nonen-1-al + NADPH + H+
?
show the reaction diagram
-
-
-
?
xylitol + NAD(P)+
D-xylose + NAD(P)H + H+
show the reaction diagram
additional information
?
-