1.1.1.209: 3(or 17)alpha-hydroxysteroid dehydrogenase

This is an abbreviated version!
For detailed information about 3(or 17)alpha-hydroxysteroid dehydrogenase, go to the full flat file.

3(17)alpha-hydroxysteroid dehydrogenase, 3beta- and 17beta-hydroxysteroid dehydrogenase, AKR1C21, dehydrogenase, 3(17)alpha-hydroxy steroid, More

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Results	in table
25	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
11	Cofactor
4	Crystallization (Commentary)
4	Disease/ Diagnostics
2	Expression
2	General Information
11	IC50 Value
22	Inhibitors
36	kcat/KM [mM/s]
75	KM Value [mM]
2	Localization
5	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
11	Organism
1	Pathway
6	PDB ID
3	pH Optimum
4	Protein Variants
4	Purification (Commentary)
1	Reaction
3	Reaction Type
11	Reference
12	Source Tissue
4	Specific Activity [micromol/min/mg]
1	Storage Stability
70	Substrates and Products (Substrate)
3	Subunits
13	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
58	Turnover Number [1/s]

Natural Substrates Products on EC 1.1.1.209 - 3(or 17)alpha-hydroxysteroid dehydrogenase

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21-hydroxy-5beta-pregnane-3,20-dione + NADPH

21-hydroxy-5beta-pregnane-20alpha-ol-3-one + NADP+

5beta-pregnane-3alpha,20alpha-diol + NADPH + H+

5beta-pregnane-20alpha-ol-3-one + NADP+

androstenedione + NADPH + H+

androsterone + NADP+

additional information

the enzyme catalyses the oxidoreduction of steroid hormones such as estrogens, androgens and neurosteroids