1.1.1.206: tropinone reductase I
This is an abbreviated version!
For detailed information about tropinone reductase I, go to the full flat file.
Word Map on EC 1.1.1.206
-
1.1.1.206
-
tropane
-
reductases
-
hyoscyamine
-
scopolamine
-
datura
-
pseudotropine
-
stramonium
-
solanaceae
-
calystegines
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putrescine
-
n-methyltransferase
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solanaceous
-
3-quinuclidinone
-
synthesis
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nortropane
- 1.1.1.206
-
tropane
- reductases
- hyoscyamine
- scopolamine
- datura
- pseudotropine
- stramonium
- solanaceae
-
calystegines
- putrescine
- n-methyltransferase
-
solanaceous
- 3-quinuclidinone
- synthesis
-
nortropane
Reaction
Synonyms
BaTRI, dehydrogenase, tropine, DnTR1, DsTRI, EC 1.1.1.293, More, TR-I, TR1, TRI, Tri2, tropine biosynthetic tropinone reductase, Tropine dehydrogenase, tropine-forming reductase, tropine-forming tropinone reductase, tropinone reductase, tropinone reductase I, tropinone reductase II, tropinone reductase-I, tropinone reductase-I 2, WcTR-I, WsTR-I, WsTR-I protein
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Reference on EC 1.1.1.206 - tropinone reductase I
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Koelen, K.J.; Gross, G.G.
Partial purification and properties of tropine dehydrogenase from root cultures of Datura stramonium
J. Med. Plant Res.
44
227-230
1982
Datura stramonium
Nakajima, K.; Hashimoto, T.; Yamada, Y.
Opposite stereospecificity of two tropinone reductases is conferred by the substrate-binding sites
J. Biol. Chem.
269
11695-11698
1994
Datura stramonium
Bartholomew, B.A.; Smith, M.J.; Long, M.T.; Darcy, P.J.; Trudgill P.W.; Hopper, K.J.
Tropine dehydrogenase: purification, some properties and an evaluation of its role in the bacterial metabolism of tropine
Biochem. J.
307
603-608
1995
Pseudomonas sp., Pseudomonas sp. AT3
-
Nakajima, K.; Kato, H.; Oda, J.; Yamada, Y.; Hashimoto, T.
Site-directed mutagenesis of putative substrate-binding residues reveals a mechanism controlling the different stereospecificities of two tropinone reductases
J. Biol. Chem.
274
16563-16568
1999
Datura stramonium
Boswell, H.D.; Dräger, B.; McLauchlan W.R.; Portsteffen, A.; Robins D.J.; Robins R.J.; Walton, N.J.
Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura
Phytochemistry
52
871-878
1999
Brugmansia sp., Datura stramonium
Hashimoto, T.; Nakajima, K.; Ongena, G.; Yamada, Y.
Two tropinone reductases with distinct stereospecificities from cultured roots of Hyoscyamus niger
Plant Physiol.
100
836-845
1992
Atropa acuminata, Atropa belladonna, Datura stramonium, Duboisia hopwoodii, Duboisia leichhardtii, Hyoscyamus albus, Hyoscyamus bohemicus, Hyoscyamus canariensis, Hyoscyamus muticus, Hyoscyamus niger, Hyoscyamus pusillus, no activity in Brassica campestris, no activity in Browallia americana, no activity in Calystegia sepium, no activity in Nicotiana tabacum, no activity in Physalis alkekengi, Physalis edulis, Physalis philadelphica, Physochlaina orientalis, Hyoscyamus niger Hn
Nakajima, K.; Yamashita, A.; Akama, H.; Nakatsu, T.; Kato, H.; Hashimoto, T.; Oda, J.; Yamada, Y.
Crystal structures of two tropinone reductases: Different reaction stereospecificities in the same protein fold
Proc. Natl. Acad. Sci. USA
95
4876-4881
1998
Datura stramonium
Rocha, P.; Stenzel, O.; Parr, A.; Walton, N.; Christou, P.; Drager, B.; Leech, M.J.
Functional expression of tropinone reductase I (trI) and hyoscyamine-6beta-hydroxylase (h6h) from Hyoscyamus niger in Nicotiana tabacum
Plant Sci.
162
905-913
2002
Hyoscyamus niger
-
Richter, U.; Rothe, G.; Fabian, A.K.; Rahfeld, B.; Drager, B.
Overexpression of tropinone reductases alters alkaloid composition in Atropa belladonna root cultures
J. Exp. Bot.
56
645-652
2005
Atropa belladonna, Datura stramonium (P50162)
Draeger, B.
Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism
Phytochemistry
67
327-337
2006
Atropa belladonna, Datura stramonium, Duboisia leichhardtii, Duboisia myoporoides, Hyoscyamus muticus, Hyoscyamus niger, Scopolia atropoides
Brock, A.; Brandt, W.; Draeger, B.
The functional divergence of short-chain dehydrogenases involved in tropinone reduction
Plant J.
54
388-401
2008
Cochlearia officinalis (A7DY56)
Freydank, A.C.; Brandt, W.; Draeger, B.
Protein structure modeling indicates hexahistidine-tag interference with enzyme activity
Proteins
72
173-183
2008
Solanum dulcamara
Kai, G.; Li, L.; Jiang, Y.; Yan, X.; Zhang, Y.; Lu, X.; Liao, P.; Chen, J.
Molecular cloning, characterization of two tropinone reductases in Anisodus acutangulus and enhancement of tropane alkaloids production in AaTRI-transformed hairy roots
Biotechnol. Appl. Biochem.
54
:177-186
2009
Anisodus acutangulus (B2L2W8)
Kai, G.; Yang, S.; Luo, X.; Zhou, W.; Fu, X.; Zhang, A.; Zhang, Y.; Xiao, J.
Co-expression of AaPMT and AaTRI effectively enhances the yields of tropane alkaloids in Anisodus acutangulus hairy roots
BMC Biotechnol.
11
43
2011
Anisodus acutangulus (B2L2W8), Anisodus acutangulus
Kushwaha, A.K.; Sangwan, N.S.; Tripathi, S.; Sangwan, R.S.
Molecular cloning and catalytic characterization of a recombinant tropine biosynthetic tropinone reductase from Withania coagulans leaf
Gene
516
238-247
2013
Withania coagulans (L7QI79), Withania coagulans
Kai, G.; Zhang, A.; Guo, Y.; Li, L.; Cui, L.; Luo, X.; Liu, C.; Xiao, J.
Enhancing the production of tropane alkaloids in transgenic Anisodus acutangulus hairy root cultures by over-expressing tropinone reductase I and hyoscyamine-6beta-hydroxylase
Mol. Biosyst.
8
2883-2890
2012
Anisodus acutangulus (B2L2W8), Anisodus acutangulus
Dehghan, E.; Shahriari Ahmadi, F.; Ghotbi Ravandi, E.; Reed, D.W.; Covello, P.S.; Bahrami, A.R.
An atypical pattern of accumulation of scopolamine and other tropane alkaloids and expression of alkaloid pathway genes in Hyoscyamus senecionis
Plant Physiol. Biochem.
70C
188-194
2013
Hyoscyamus muticus, Hyoscyamus senecionis
Cheng, X.; Chen, W.; Zhou, Z.; Liu, J.; Wang, H.
Functional characterization of a novel tropinone reductase-like gene in Dendrobium nobile Lindl
J. Plant Physiol.
170
958-964
2013
Dendrobium nobile (H9BQR7)
Chen, W.; Cheng, X.; Zhou, Z.; Liu, J.; Wang, H.
Molecular cloning and characterization of a tropinone reductase from Dendrobium nobile Lindl
Mol. Biol. Rep.
40
1145-1154
2013
Dendrobium nobile (H9BQR7), Dendrobium nobile
Qiang, W.; Xia, K.; Zhang, Q.; Zeng, J.; Huang, Y.; Yang, C.; Chen, M.; Liu, X.; Lan, X.; Liao, Z.
Functional characterisation of a tropine-forming reductase gene from Brugmansia arborea, a woody plant species producing tropane alkaloids
Phytochemistry
127
12-22
2016
Brugmansia arborea (A0A088MI02), Brugmansia arborea, Datura stramonium (P50162), Datura stramonium
Kuester, N.; Rosahl, S.; Draeger, B.
Potato plants with genetically engineered tropane alkaloid precursors
Planta
245
355-365
2017
Solanum tuberosum (Q9AR59), Solanum tuberosum
Kushwaha, A.K.; Sangwan, N.S.; Trivedi, P.K.; Negi, A.S.; Misra, L.; Sangwan, R.S.
Tropine forming tropinone reductase gene from Withania somnifera (Ashwagandha): biochemical characteristics of the recombinant enzyme and novel physiological overtones of tissue-wide gene expression patterns
PLoS ONE
8
e74777
2013
Withania somnifera (U5PUZ1), Withania somnifera
Wu, N.; Jian, D.; Xiang, M.; Chen, M.; Lan, X.; Liao, Z.; Liu, X.
Biochemical characterization reveals the functional divergence of two tropinone reductases from Przewalskia tangutica
Biotechnol. Appl. Biochem.
66
597-606
2019
Przewalskia tangutica (A0A6B7HCZ2), Przewalskia tangutica
Zhao, K.; Zeng, J.; Zhao, T.; Zhang, H.; Qiu, F.; Yang, C.; Zeng, L.; Liu, X.; Chen, M.; Lan, X.; Liao, Z.
Enhancing tropane alkaloid production based on the functional identification of tropine-forming reductase in Scopolia lurida, a tibetan medicinal plant
Front. Plant Sci.
8
1745
2017
Anisodus luridus (R4QQK2)
Qiang, W.; Xia, K.; Zhao, X.; Fu, W.; Man, J.; Zhang, M.
Cloning and enzymatic function characterization of a novel tropinone reductase I (DaTRI 2) in Datura arborea
Yao Xue Xue Bao
54
574-581
2019
Brugmansia arborea (A0A482P6A8)
-
Dehghan, E.; Reed, D.W.; Covello, P.S.; Hasanpour, Z.; Palazon, J.; Oksman-Caldentey, K.M.; Ahmadi, F.S.
Genetically engineered hairy root cultures of Hyoscyamus senecionis and H. muticus ploidy as a promising parameter in the metabolic engineering of tropane alkaloids
Plant Cell Rep.
36
1615-1626
2017
Hyoscyamus muticus, Hyoscyamus senecionis, Hyoscyamus muticus Cairo
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