1.1.1.200: aldose-6-phosphate reductase (NADPH)

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For detailed information about aldose-6-phosphate reductase (NADPH), go to the full flat file.

Reaction

Synonyms

A6PR, A6PR1, A6PR2, A6PRase, Ald6PRase, alditol 6-phosphate:NADP 1-oxidoreductase, aldose-6-P reductase, aldose-6-phosphate reductase, aldose-6-phosphate reductase [NADPH], NADP-S6PDH, NADPH-dependent aldose 6-phosphate reductase, reductase, aldose 6-phosphate, S6PDH, sorbitol-6-phosphate dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.200 aldose-6-phosphate reductase (NADPH)

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Results	in table
1	Activating Compound
9	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
14	Cofactor
6	Expression
2	General Information
1	General Stability
28	Inhibitors
5	Ki Value [mM]
12	KM Value [mM]
2	Localization
3	Metals/Ions
7	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
18	Organism
1	Oxidation Stability
1	Pathway
2	PDB ID
1	pH Optimum
2	pH Range
1	pI Value
5	Purification (Commentary)
1	Reaction
3	Reaction Type
16	Reference
19	Source Tissue
15	Specific Activity [micromol/min/mg]
2	Storage Stability
31	Substrates and Products (Substrate)
7	Subunits
23	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Turnover Number [1/s]

pH Range

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pH Range on EC 1.1.1.200 - aldose-6-phosphate reductase (NADPH)

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

6 - 10

Malus domestica

P28475

N- and the C-term tagged enzymes. Both recombinant enzymes similarly show optimal activity in a broad pH range in the direction of D-glucose 6-phosphate reduction, and a narrow range (pH 9.0-10.0) in the opposite oxidative direction

696497

8.5 - 10.1

Malus domestica

-

about 50% of activity maximum at pH 8.5 and 10.1

347839