1.1.1.200: aldose-6-phosphate reductase (NADPH)

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For detailed information about aldose-6-phosphate reductase (NADPH), go to the full flat file.

Reaction

Synonyms

A6PR, A6PR1, A6PR2, A6PRase, Ald6PRase, alditol 6-phosphate:NADP 1-oxidoreductase, aldose-6-P reductase, aldose-6-phosphate reductase, aldose-6-phosphate reductase [NADPH], NADP-S6PDH, NADPH-dependent aldose 6-phosphate reductase, reductase, aldose 6-phosphate, S6PDH, sorbitol-6-phosphate dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.200 aldose-6-phosphate reductase (NADPH)

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Results	in table
1	Activating Compound
9	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
14	Cofactor
6	Expression
2	General Information
1	General Stability
28	Inhibitors
5	Ki Value [mM]
12	KM Value [mM]
2	Localization
3	Metals/Ions
7	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
18	Organism
1	Oxidation Stability
1	Pathway
2	PDB ID
1	pH Optimum
2	pH Range
1	pI Value
5	Purification (Commentary)
1	Reaction
3	Reaction Type
16	Reference
19	Source Tissue
15	Specific Activity [micromol/min/mg]
2	Storage Stability
31	Substrates and Products (Substrate)
7	Subunits
23	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Turnover Number [1/s]

Expression

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Expression on EC 1.1.1.200 - aldose-6-phosphate reductase (NADPH)

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

At 400 mM sucrose and 400 mM fructose, transcription increases by approximately 4fold. Palatinose increases the enzyme transcription much more drastically than sucrose. Mannose and 3-O-methylglucose also increase enzyme transcription

Rhaphiolepis bibas

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741115

enzyme expression is upregulated during drought and salt stress. Transcript in wild type tomato leaves increases significantly during drought and salt stress when compared with the well-watered control and is 2.2fold and 2.1fold that of the control, respectively

Solanum lycopersicum

-

761187

enzyme transcription is decreased to 40% by 800 mM sorbitol

Rhaphiolepis bibas

-

741115

isoform A6PR1 transcripts increase in roots in cold stress (4°C). Isoform A6PR2 responds positively in roots under salt stress (150 mM NaCl)

Arabidopsis thaliana

-

761738

isoform A6PR2 levels decrease in both roots and rosette leaves in cold stress (4°C). Isoform A6PR1 levels fall in leaves under salt stress (150 mM NaCl)

Arabidopsis thaliana

-

761738

the enzyme shows significantly increased activity and expression above the control levels after 2 days without watering, whereas enzyme activity decreases on the following day but returns to the control level 2 days after rewatering

Malus domestica

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762168