1.1.1.188: prostaglandin-F synthase
This is an abbreviated version!
For detailed information about prostaglandin-F synthase, go to the full flat file.
Reaction
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Synonyms
17beta-hydroxysteroid dehydrogenase type 5, 17betaHSD5, 20alpha-HSD/PGFS, 20alpha-hydroxysteroid dehydrogenase/prostaglandin F-synthase, 9,11-endoperoxidase reductase, AKR1B1, AKR1B3, AKR1B7, AKR1C3, Akr1cl, aldo-keto reductase, aldo-keto reductase 1C3, aldo-ketoreductase 1B1, ALDR1, ALR2, DD1, dihydrodiol dehydrogenase 1, LBRM2904_31.2170, LemaA.00019.a.B1, m-PGFS, More, NADPH-dependent prostaglandin D2 11-keto reductase, P100/11E, PG endoperoxide reductase, PGD 11-ketoreductase, PGD2 11-ketoreductase, PGF, PGF synthase, PGF synthase I, PGF synthase II, PGF2alpha synthase, PGF2alpha-synthase, PGF2alpha-synthetic activity, PGF2S, PGFS, PGFS I, PGFS-I, PGFS-II, PGFSI, PGFSII, PGH 9-,11-endoperoxide reductase, PGH2 9,11-endoperoxidase, PGH2 9,11-endoperoxide reductase, PGH2 9-,11-endoperoxide reductase, prostaglandin 11-keto reductase, prostaglandin 11-ketoreductase, prostaglandin D2 11-ketoreductase, prostaglandin D2-ketoreductase, prostaglandin F synthase, prostaglandin F synthase I, prostaglandin F synthase II, prostaglandin F synthetase, prostaglandin F2alpha synthase, prostaglandin F2alpha-synthase, prostaglandin-D2 11-reductase, prostaglandin-F2alpha synthase, prostamide/PGF synthase, prostamide/prostaglandin F synthase, reductase, 15-hydroxy-11-oxoprostaglandin, synthetase, prostaglandin F2alpha, Tc00.1047053508461.80, Tc00.1047053511287.49, TCDM_00059, TrcrA.00019.a.B1, type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase, vas deferens protein
ECTree
KM Value
KM Value on EC 1.1.1.188 - prostaglandin-F synthase
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0.134
(5Z,13E)-(15S)-9alpha,11beta,15-trihydroxyprosta-5,13-dienoate
-
-
0.0119 - 0.013
4-Nitroacetophenone
0.0008 - 0.125
4-nitrobenzaldehyde
0.0031
5beta-androstan-3,17-dione
-
-
0.001
5beta-Androstan-3alpha-ol-17-one
-
-
0.0175
5beta-dihydrotestosterone
0.0001 - 0.002
9,10-phenanthrenequinone
0.03 - 0.28
9alpha,11beta-prostaglandin F2
0.0066
androst-4-ene-3,17-dione
pH 7.0, 37°C
0.0031 - 0.018
Hydrindantin
0.0119
p-nitroacetophenone
-
-
0.02 - 0.08
Phenylglyoxal
0.25
Prostaglandin A2
-
lung enzyme
0.003 - 2
Prostaglandin D2
0.0013 - 0.033
prostaglandin H2
0.015 - 0.18
prostaglandin PGD2
0.003 - 0.03
prostaglandin PGH2
additional information
additional information
kinetics of 3alpha-hydroxysteroid dehydrogenase type II activity
-
0.0119
4-Nitroacetophenone
-
37°C, liver-type isozyme
0.013
4-Nitroacetophenone
-
lung enzyme
0.0008
4-nitrobenzaldehyde
-
-
0.0008
4-nitrobenzaldehyde
-
liver enzyme
0.0083
4-nitrobenzaldehyde
-
lung enzyme
0.0143
4-nitrobenzaldehyde
-
-
0.0143
4-nitrobenzaldehyde
-
37°C, liver-type isozyme
0.0774
4-nitrobenzaldehyde
-
-
0.125
4-nitrobenzaldehyde
-
lung enzyme
0.0175
5beta-dihydrotestosterone
-
-
0.0175
5beta-dihydrotestosterone
-
37°C, liver-type isozyme
0.0001
9,10-phenanthrenequinone
-
expressed lung enzyme
0.00013
9,10-phenanthrenequinone
-
lung enzyme
0.00042
9,10-phenanthrenequinone
-
-
0.0007
9,10-phenanthrenequinone
-
native lung prostaglandin F synthase
0.0008
9,10-phenanthrenequinone
-
-
0.001
9,10-phenanthrenequinone
-
liver enzyme
0.0011
9,10-phenanthrenequinone
-
expressed liver prostaglandin F synthase
0.0011
9,10-phenanthrenequinone
-
recombinant wild-type liver-type isozyme, 37°C
0.0015
9,10-phenanthrenequinone
pH 7.0, 37°C
0.002
9,10-phenanthrenequinone
-
-
0.002
9,10-phenanthrenequinone
-
native liver prostaglandin F synthase
0.002
9,10-phenanthrenequinone
-
37°C, liver-type isozyme
0.03
9alpha,11beta-prostaglandin F2
wild-type, pH 7, 37°C
0.28
9alpha,11beta-prostaglandin F2
mutant P85W, pH 7, 37°C
0.053
cyclohexanone
-
-
0.053
cyclohexanone
-
37°C, liver-type isozyme
0.143
DL-glyceraldehyde
-
-
0.143
DL-glyceraldehyde
-
37°C, liver-type isozyme
0.0031
Hydrindantin
-
-
0.0031
Hydrindantin
-
37°C, liver-type isozyme
0.018
Hydrindantin
-
lung enzyme
0.013
menadione
-
lung enzyme
0.0167
menadione
-
37°C, liver-type isozyme
0.1
menadione
-
liver enzyme
0.0027
NADPH
wild-type, pH 7, 37°C
0.02
Phenylglyoxal
-
-
0.02
Phenylglyoxal
-
37°C, liver-type isozyme
0.08
Phenylglyoxal
-
lung enzyme
0.007
prostaglandin D1
-
-
0.007
prostaglandin D1
-
37°C, liver-type isozyme
0.003
Prostaglandin D2
wild-type, pH 7, 37°C
0.0034
Prostaglandin D2
-
-
0.01
Prostaglandin D2
-
-
0.01
Prostaglandin D2
-
native liver prostaglandin F synthase
0.01
Prostaglandin D2
-
37°C, liver-type isozyme
0.015
Prostaglandin D2
-
expressed liver prostaglandin F synthase
0.1
Prostaglandin D2
-
lung enzyme
0.1
Prostaglandin D2
-
expressed lung enzyme
0.12
Prostaglandin D2
-
native lung prostaglandin F synthase
0.12
Prostaglandin D2
-
37°C, lung-type isozyme
0.174
Prostaglandin D2
-
-
0.2
Prostaglandin D2
-
liver enzyme
0.0056
Prostaglandin D3
-
-
0.0056
Prostaglandin D3
-
37°C, liver-type isozyme
0.0013
prostaglandin H2
-
-
0.0019
prostaglandin H2
-
0.0038
prostaglandin H2
-
AKR1B7
0.0069
prostaglandin H2
-
pH 7.0, 24°C
0.008
prostaglandin H2
-
expressed lung enzyme
0.0093
prostaglandin H2
-
AKR1B3
0.01
prostaglandin H2
-
native lung prostaglandin F synthase
0.025
prostaglandin H2
-
-
0.025
prostaglandin H2
-
native and expressed liver prostaglandin F synthase
0.025
prostaglandin H2
-
37°C, liver-type isozyme
0.029
prostaglandin H2
pH 5.5, 37°C
0.033
prostaglandin H2
-
pH 5.0, 37°C
0.015
prostaglandin PGD2
-
recombinant wild-type liver-type isozyme, 37°C
0.04
prostaglandin PGD2
-
recombinant liver-type isozyme mutant S301R, 37°C
0.05
prostaglandin PGD2
-
recombinant liver-type isozyme mutant K225S, 37°C
0.075
prostaglandin PGD2
-
recombinant liver-type isozyme mutant H170C, 37°C
0.1
prostaglandin PGD2
-
recombinant liver-type isozyme mutant N306Y, 37°C
0.11
prostaglandin PGD2
-
recombinant liver-type isozyme mutant R27E, 37°C
0.12
prostaglandin PGD2
-
recombinant wild-type lung-type isozyme
0.145
prostaglandin PGD2
-
recombinant liver-type isozyme mutant R91Q, 37°C
0.18
prostaglandin PGD2
-
recombinant liver-type isozyme mutant R223L, 37°C
0.003
prostaglandin PGH2
-
recombinant liver-type isozyme, mutant H170C, 37°C
0.01
prostaglandin PGH2
-
recombinant liver-type isozyme, mutants R91Q, R223L and N306Y, 37°C
0.014
prostaglandin PGH2
-
recombinant liver-type isozyme, mutant R27E, 37°C
0.025
prostaglandin PGH2
-
recombinant wild-type liver-type isozyme, 37°C
0.028
prostaglandin PGH2
-
recombinant liver-type isozyme, mutant K225S, 37°C
0.03
prostaglandin PGH2
-
recombinant liver-type isozyme, mutant S301R, 37°C