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1.1.1.168: 2-dehydropantolactone reductase (Re-specific)

This is an abbreviated version!
For detailed information about 2-dehydropantolactone reductase (Re-specific), go to the full flat file.

Word Map on EC 1.1.1.168

Reaction

(R)-pantolactone
+
NADP+
=
2-dehydropantolactone
 +
NADPH
 +
H+

Synonyms

(R)-pantoyl-lactone:NADP+ oxidoreductase (A-specific), 2-dehydropantoyl-lactone reductase, 2-dehydropantoyl-lactone reductase (A-specific), 2-ketopantoyl lactone reductase, AKR, CPR, ketopantoyl lactone reductase, NADPH-dependent aldo-keto reductase, NADPH-dependent conjugated polyketone reductase, reductase, 2-oxopantoyl lactone

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.168 2-dehydropantolactone reductase (Re-specific)

Temperature Stability

Temperature Stability on EC 1.1.1.168 - 2-dehydropantolactone reductase (Re-specific)

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30 - 50
the residual activity of recombinant enzyme maintains above 90% of the initial activity after 7 h at 30°C. When the enzyme is incubated at 50°C, above 30% of the initial activity still retains after 2 h. The recombinant enzyme exhibits adequate thermal stability, and its half-lives are 45.6, 8.6 and 1.7 h at 30, 40 and 50°C, respectively
40
-
pH 7.0, 10 min, 58% loss of activity
40 - 50
the recombinant enzyme exhibits high thermal stability with half-lives of 6.3 h, 3.7 h and 52 min at 40, 45 and 50°C, respectively
56
-
0.35 M anhydrous sodium sulfate, complete inactivation
60
-
pH 7.0, 10 min, 77% loss of activity