1.1.1.146: 11beta-hydroxysteroid dehydrogenase

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For detailed information about 11beta-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

Synonyms

11 beta-hydroxysteroid dehydrogenase type 1, 11-beta hydroxysteroid dehydrogenase type 1, 11-beta-HSD1, 11-beta-HSD1 (oxidase) NADP+, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type1, 11-DH, 11-DH2, 11-oxoreductase, 11beta hydroxysteroid dehydrogenase type 1, 11beta-HSD, 11beta-HSD 1, 11beta-HSD type 1, 11beta-HSD-1, 11beta-HSD-2, 11beta-HSD1, 11beta-HSD1A, 11beta-HSD2, 11beta-hydroxy steroid dehydrogenase, 11beta-hydroxy steroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase, 11beta-hydroxysteroid dehydrogenase 1, 11beta-hydroxysteroid dehydrogenase 2, 11beta-hydroxysteroid dehydrogenase isoforms 1, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type I, 11beta-hydroxysteroid dehydrogenase type-1, 11beta-hydroxysteroid dehydrogenase-1, 11beta-hydroxysteroid dehydrogenases type 1, 11beta-hydroxysteroid type 1 dehydrogenase, 11beta-hydroxysteroid-dehydrogenase type I, 11betaHSD1, 11betaHSD2, 11HSD1, beta-hydroxysteroid dehydrogenase, corticosteroid 11-reductase, corticosteroid 11beta-dehydrogenase, dehydrogenase, 11beta-hydroxy steroid, HSD1, HSD11B, HSD11B1, Hsd11B2, HSD2, hydroxysteroid (11-beta) dehydrogenase, isozyme 11beta-HSD1, More, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, NADP(+)-dependent 11beta-dehydrogenase, NADP+-dependent 11beta-hydroxysteroid dehydrogenase 1, type 1 11beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.146 11beta-hydroxysteroid dehydrogenase

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Results	in table
22	Activating Compound
60	AA Sequence
30	Application
1	CAS Registry Number
67	Cloned(Commentary)
188	Cofactor
10	Crystallization (Commentary)
3399	Disease/ Diagnostics
18	Expression
16	General Information
1	General Stability
1306	IC50 Value
1759	Inhibitors
67	Ki Value [mM]
126	KM Value [mM]
91	Localization
8	Metals/Ions
23	Molecular Weight [Da]
214	Natural Substrates/ Products (Substrates)
299	Organism
4	Pathway
185	PDB ID
25	pH Optimum
2	pH Range
2	pH Stability
15	Posttranslational Modification
27	Protein Variants
28	Purification (Commentary)
7	Reaction
3	Reaction Type
283	Reference
362	Source Tissue
15	Specific Activity [micromol/min/mg]
7	Storage Stability
429	Substrates and Products (Substrate)
21	Subunits
396	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
1	Temperature Stability [°C]
10	Turnover Number [1/s]

Storage Stability

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Storage Stability on EC 1.1.1.146 - 11beta-hydroxysteroid dehydrogenase

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-15°C, acetone-dried powder of washed microsomes, oxidating activity 3 months, reducing activity 2 months

Rattus sp.

-

285967

-15�C, purified microsomes stored as frozen pellets, retain their ability to oxidize cortisol to cortisone with little loss in activity over several months, their ability to reduce cortisone to cortisol declines fairly rapidly to 30% of maximal activity within 30 days, the stability of acetone-dried powders of washed microsomes is high, and oxidizing activity is stable for 3 months, reducing activity for up to 2 months

2 entries

-20�C, 0.01 M sodium phosphate, pH 7.4, 0.25 M sucrose, 6 weeks

2 entries

-20°C, 1 mM NADP+, several months

Rattus sp.

-

285961

-70°C, 0.01 M sodium phosphate, pH 7.0, 0.25 M sucrose, 6 weeks

Cavia porcellus

-

285960

-15�C, purified microsomes stored as frozen pellets, retain their ability to oxidize cortisol to cortisone with little loss in activity over several months, their ability to reduce cortisone to cortisol declines fairly rapidly to 30% of maximal activity within 30 days, the stability of acetone-dried powders of washed microsomes is high, and oxidizing activity is stable for 3 months, reducing activity for up to 2 months

Cavia porcellus

-

285967

-15�C, purified microsomes stored as frozen pellets, retain their ability to oxidize cortisol to cortisone with little loss in activity over several months, their ability to reduce cortisone to cortisol declines fairly rapidly to 30% of maximal activity within 30 days, the stability of acetone-dried powders of washed microsomes is high, and oxidizing activity is stable for 3 months, reducing activity for up to 2 months

Rattus norvegicus

-

285967

-20�C, 0.01 M sodium phosphate, pH 7.4, 0.25 M sucrose, 6 weeks

Rattus norvegicus

-

285958

-20�C, 0.01 M sodium phosphate, pH 7.4, 0.25 M sucrose, 6 weeks

Rattus sp.

-

285958