1.1.1.146: 11beta-hydroxysteroid dehydrogenase

This is an abbreviated version!
For detailed information about 11beta-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

Synonyms

11 beta-hydroxysteroid dehydrogenase type 1, 11-beta hydroxysteroid dehydrogenase type 1, 11-beta-HSD1, 11-beta-HSD1 (oxidase) NADP+, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type1, 11-DH, 11-DH2, 11-oxoreductase, 11beta hydroxysteroid dehydrogenase type 1, 11beta-HSD, 11beta-HSD 1, 11beta-HSD type 1, 11beta-HSD-1, 11beta-HSD-2, 11beta-HSD1, 11beta-HSD1A, 11beta-HSD2, 11beta-hydroxy steroid dehydrogenase, 11beta-hydroxy steroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase, 11beta-hydroxysteroid dehydrogenase 1, 11beta-hydroxysteroid dehydrogenase 2, 11beta-hydroxysteroid dehydrogenase isoforms 1, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type I, 11beta-hydroxysteroid dehydrogenase type-1, 11beta-hydroxysteroid dehydrogenase-1, 11beta-hydroxysteroid dehydrogenases type 1, 11beta-hydroxysteroid type 1 dehydrogenase, 11beta-hydroxysteroid-dehydrogenase type I, 11betaHSD1, 11betaHSD2, 11HSD1, beta-hydroxysteroid dehydrogenase, corticosteroid 11-reductase, corticosteroid 11beta-dehydrogenase, dehydrogenase, 11beta-hydroxy steroid, HSD1, HSD11B, HSD11B1, Hsd11B2, HSD2, hydroxysteroid (11-beta) dehydrogenase, isozyme 11beta-HSD1, More, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, NADP(+)-dependent 11beta-dehydrogenase, NADP+-dependent 11beta-hydroxysteroid dehydrogenase 1, type 1 11beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.146 11beta-hydroxysteroid dehydrogenase

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Results	in table
22	Activating Compound
60	AA Sequence
30	Application
1	CAS Registry Number
67	Cloned(Commentary)
188	Cofactor
10	Crystallization (Commentary)
3399	Disease/ Diagnostics
18	Expression
16	General Information
1	General Stability
1306	IC50 Value
1759	Inhibitors
67	Ki Value [mM]
126	KM Value [mM]
91	Localization
8	Metals/Ions
23	Molecular Weight [Da]
214	Natural Substrates/ Products (Substrates)
299	Organism
4	Pathway
185	PDB ID
25	pH Optimum
2	pH Range
2	pH Stability
15	Posttranslational Modification
27	Protein Variants
28	Purification (Commentary)
7	Reaction
3	Reaction Type
283	Reference
362	Source Tissue
15	Specific Activity [micromol/min/mg]
7	Storage Stability
429	Substrates and Products (Substrate)
21	Subunits
396	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
1	Temperature Stability [°C]
10	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.1.1.146 - 11beta-hydroxysteroid dehydrogenase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

5-aminoimidazole-4-carboxamide ribonucleoside

Mus musculus

-

treatment augments the induction of enzyme expression and activity by C2 ceramide

686411

bacterial sphingomyelinase

Mus musculus

-

-

686411

-

C2 ceramide

Mus musculus

-

treatment of 3T3-L1 preadipocytes robustly induces the expression of isoform 11beta-HSD1 via induction of CCAAT/enhancer-binding protein beta and its binding to the 11beta-HSD1 promoter

686411

D-glucose 6-phosphate

2 entries

dehydroandrostenedione

Rattus norvegicus

-

activates isozyme 11beta-HSD1 3fold

669504

dexamethasone

Homo sapiens

-

after application of dexamethasone, 11beta-HSD1 mRNA increases in muscle of both diabetic and control subjects, whereas 11beta-HSD2 mRNA decreases. 11beta-HSD1 activity increases in diabetic subjects, but not in controls, whereas 11beta-HSD2 activity does not change in either group

687961

glucose

2 entries

Insulin

2 entries

-

norepinephrine

Rattus norvegicus

-

activates isozyme 11beta-HSD1 2.5fold

669504

sphingosine 1-phosphate

Mus musculus

-

-

686411

Triton DF-18

3 entries

-

Triton X-100

Rattus sp.

-

slight activation

285962

additional information

5 entries

-

D-glucose 6-phosphate

Homo sapiens

P28845

stimulates isoform 11beta-HSD1 reductase activity in liver but not in testis

741248

D-glucose 6-phosphate

Rattus norvegicus

-

stimulates isoform 11beta-HSD1 reductase activity in liver but not in testis

741248

glucose

Homo sapiens

-

coexpression with hexose-6-phosphate dehydrogenase potentiates 11beta-HSD1 reductase activity at high glucose, this effect is significantly decreased at low glucose, with concomitantly increased 11beta-HSD1 dehydrogenase activity

700180

glucose

Mus musculus

-

coexpression with hexose-6-phosphate dehydrogenase potentiates 11beta-HSD1 reductase activity at high glucose, this effect is significantly decreased at low glucose, with concomitantly increased 11beta-HSD1 dehydrogenase activity

700180

Insulin

Mus musculus

-

insulin stimulates 11beta-HSD1 activity and expression in a time- and concentration-dependent manner, the p38 MAPK inhibitor SB-220025, but not the ERK inhibitor U-0126 or the phosphatidylinositol 3-kinase inhibitor LY294002, prevent insulin stimulation of 11beta-HSD1 activity

697625

-

Insulin

Rattus norvegicus

-

insulin stimulates 11beta-HSD1 activity and expression in a time- and concentration-dependent manner, the p38 MAPK inhibitor SB-220025, but not the ERK inhibitor U-0126 or the phosphatidylinositol 3-kinase inhibitor LY294002, prevent insulin stimulation of 11beta-HSD1 activity

697625

-

Triton DF-18

Mammalia

-

microsome-linked property to detergent-dependent release of activity for all mammalian, but not for rat enzyme

285964

-

Triton DF-18

Rattus sp.

-

-

285964

-

Triton DF-18

Rattus sp.

-

slight activation

285962

-

additional information

Bos taurus

-

the conversion rate of cortisone to cortisol is significantly stimulated by 0.001 and 0.01 mM prostaglandin F2alpha, but not by prostaglandin E2. Although prostaglandin F2alpha (0.001 mM) does not affect the expression of HSD11B in cultured stromal cells, it significantly stimulates the protein expression of HSD11B. Cycloheximide abolishes the stimulatory effect of prostaglandin F2alpha on HSD11B protein expression in endometrial stromal cells, indicating that prostaglandin F2alpha increases HSD11B1 protein expression by stimulating a posttranscriptional process rather than a transcriptional mechanism.

696570

-

additional information

Homo sapiens

-

isozyme 11beta-HSD1 is induced by cortisol, mechanism through induction of promoter activity, overview

668424

-

additional information

Homo sapiens

-

interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2

700178

-

additional information

Mus musculus

-

11beta-HSD2mRNA expression increases 2.5fold on day 3 after injection of trehalose-6,6'-dimycolate

700441

-

additional information

Mus musculus

-

interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2

700178

-