1.1.1.141: 15-hydroxyprostaglandin dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about 15-hydroxyprostaglandin dehydrogenase (NAD+), go to the full flat file.

Reaction

Synonyms

11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase, 15-hydroxy prostaglandin dehydrogenase, 15-hydroxy-prostaglandin-dehydrogenase, 15-hydroxyprostaglandin dehydrogenase, 15-hydroxyprostaglandin-dehydrogenase, 15-hydroxyprostanoic dehydrogenase, 15-OH-PGDH, 15-PGDH, 15-prostaglandin dehydrogenase, dehydrogenase, 15-hydroxyprostaglandin, HPGD, NAD+ dependent 15-hydroxyprostaglandin dehydrogenase, NAD+ dependent PGDH, NAD+-15-hydroxy prostanoate oxidoreductase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I), NAD+-dependent 15-PGDH, NAD+-linked 15-hydroxyprostaglandin dehydrogenase, NAD-dependent 15-hydroxyprostaglandin dehydrogenase, NAD-specific 15-hydroxyprostaglandin dehydrogenase, nicotinamide adenine dinucleotide-dependent 15-hydroxyprostaglandin dehydrogenase, PGDH, prostaglandin dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+)

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Results	in table
30	Activating Compound
43	AA Sequence
9	Application
1	CAS Registry Number
23	Cloned(Commentary)
62	Cofactor
1	Crystallization (Commentary)
1263	Disease/ Diagnostics
11	Expression
9	General Information
7	General Stability
108	IC50 Value
268	Inhibitors
7	kcat/KM [mM/s]
38	Ki Value [mM]
100	KM Value [mM]
8	Localization
19	Molecular Weight [Da]
51	Natural Substrates/ Products (Substrates)
164	Organism
6	Pathway
1	PDB ID
19	pH Optimum
2	pH Range
70	Protein Variants
34	Purification (Commentary)
9	Reaction
3	Reaction Type
101	Reference
226	Source Tissue
24	Specific Activity [micromol/min/mg]
8	Storage Stability
175	Substrates and Products (Substrate)
14	Subunits
121	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
4	Temperature Stability [°C]
25	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.1.1.141 - 15-hydroxyprostaglandin dehydrogenase (NAD+)

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

23 entries

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

Homo sapiens

-

-

667147

i.e. 15-hydroxyprostaglandin or (15S)-PGE2

-

r

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

4 entries

15-hydroxyprostaglandin + NAD+

15-oxoprostaglandin + NADH + H+

3 entries

prostaglandin E2 + NAD+

15-oxoprostaglandin E2 + NADH + H+

4 entries

additional information

?

-

8 entries

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Bos taurus

-

-

285917

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Bos taurus

Q309F3

-

670868

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Canis lupus familiaris

-

first step in prostaglandin catabolism

285918

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Cavia porcellus

-

first step in prostaglandin catabolism

285918

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

-

285931, 654158, 654348, 654361, 654374, 654380, 657209, 667924, 668172

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

-

657210

-

-

r

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

catabolism of (15S)-PGE2

668162

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

first step in prostaglandin catabolism

285932

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

first step in prostaglnadin catabolism

285916

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

key step in prostaglandin catabolism, enzyme activation leads to reduced cell proliferation, the enzyme is an antagonist of ibuprofen

670734

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

key step in prostaglandin inactivation

285939

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

PGE2 degradation

669380

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

prostaglandin E2, PGE2, a proinflammatory bioactive lipid, promotes cancer progression by modulating proliferation, apoptosis, and angiogenesis, PGE2 is a downstream product cyclooxygenase and is biochemically inactivated by the enzyme

668160

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells, overview

668173

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

the enzyme is a putative cyclooxygenase-2 antagonist and and tumor suppressor

667558

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

transcriptional regulation and biological functions, the enzyme cooperates with cyclooxygenase-2 to control cellular prostaglandin levels, reciprocal regulation of the two enzymes, overview

668359

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Macaca fascicularis

-

-

348015

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Mus musculus

-

i.e. 15-hydroxyprostaglandin or (15S)-PGE2

670691

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Mus musculus

-

PGE2 degradation

669380

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Mus musculus C57/BL6J

-

i.e. 15-hydroxyprostaglandin or (15S)-PGE2

670691

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Oryctolagus cuniculus

-

first step in prostaglandin catabolism

285921

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Rattus norvegicus

-

first step in prostaglandin catabolism

285918

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Sus scrofa

-

first step in prostaglandin catabolism

285918

-

-

?

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

P15428

-

741244, 762674

-

-

?

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

-

762674

-

-

?

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Mus musculus

Q8VCC1

the enzyme catalyzes the oxidation of the 15(S)-hydroxyl group of prostaglandin E2 (PGE2), converting the proinflammatory PGE2 to the anti-inflammatory 15-keto-PGE2 (an endogenous ligand for peroxisome proliferator-activated receptor-gamma [PPAR-gamma])

763614

-

-

?

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Rattus norvegicus

-

-

739837

-

-

?

15-hydroxyprostaglandin + NAD+

15-oxoprostaglandin + NADH + H+

Homo sapiens

-

physiological inactivation of prostaglandin by catalyzing the first step in catabolism

285914

-

285914

?

15-hydroxyprostaglandin + NAD+

15-oxoprostaglandin + NADH + H+

Homo sapiens

-

physiological inactivation of prostaglandin by catalyzing the first step in catabolism

285923

-

285923

?

15-hydroxyprostaglandin + NAD+

15-oxoprostaglandin + NADH + H+

Homo sapiens

-

physiological inactivation of prostaglandin by catalyzing the first step in catabolism

285927

-

285927

?

prostaglandin E2 + NAD+

15-oxoprostaglandin E2 + NADH + H+

Homo sapiens

P15428

-

740159, 740709

-

-

?

prostaglandin E2 + NAD+

15-oxoprostaglandin E2 + NADH + H+

Homo sapiens

-

-

740709

-

-

?

prostaglandin E2 + NAD+

15-oxoprostaglandin E2 + NADH + H+

Homo sapiens

P15428

-

741014, 741035

-

-

?

prostaglandin E2 + NAD+

15-oxoprostaglandin E2 + NADH + H+

Homo sapiens

-

-

741035

-

-

?

additional information

?

-

Homo sapiens

-

dexamethasone and phorbol ester play a role in enzyme regulation in erythroleukemia cells

285931

-

-

?

additional information

?

-

Homo sapiens

-

key enzyme for metabolic inactivation of prostaglandins, enzyme levels are reduced in inflammatory bowel disease involving TNF-alpha

667147

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme is a tumor suppressor of human breast cancer, expression of the enzyme and the estrogen receptor is correlated, silencing of the enzyme results in enhanced cancer cell proliferation, the enzyme expression is silenced in vivo in cancer cells due to promoter methylation

668162

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme is involved in anti-proliferative effect of non-steroidal anti-inflammatory drugs COX-1 inhibitors on a medullary thyroid carcinoma cell line

670734

-

-

?

additional information

?

-

Homo sapiens

-

15-hydroxyprostaglandin dehydrogenase may be repressed by an epigenetic mechanism involving histone deacetylation, resulting in increased prostaglandin E2 activity in tumors

685947

-

-

?

additional information

?

-

Macaca mulatta

-

prostaglandins play an essential role in primate parturition acting on uterine contractility and on cervical ripening

670524

-

-

?

additional information

?

-

Mus musculus

-

the enzyme is an in vivo suppressor of colon tumorigenesis, mechanism of conferring increased susceptibility to colon neoplasia, overview

670691

-

-

?

additional information

?

-

Mus musculus C57/BL6J

-

the enzyme is an in vivo suppressor of colon tumorigenesis, mechanism of conferring increased susceptibility to colon neoplasia, overview

670691

-

-

?