1.1.1.140: sorbitol-6-phosphate 2-dehydrogenase
This is an abbreviated version!
For detailed information about sorbitol-6-phosphate 2-dehydrogenase, go to the full flat file.
Reaction
Synonyms
D-glucitol-6-phosphate dehydrogenase, D-sorbitol-6-phosphate 2-dehydrogenase, D-sorbitol-6-phosphate dehydrogenase, dehydrogenase, D-sorbitol 6-phosphate, Glucitol-6-phosphate dehydrogenase, GutF, GutM, GutR, HmSorD, ketosephosphate reductase, MdS6PDH, More, operon gutFRMCBA, S6PDH, sorbitol-6-P-dehydrogenase, sorbitol-6-phosphate dehydrogenase, SrlD, Stl6PDH
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Substrates Products
Substrates Products on EC 1.1.1.140 - sorbitol-6-phosphate 2-dehydrogenase
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REACTION DIAGRAM
D-dulcitol 6-phosphate + NAD+
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at 3% of reaction reaction with sorbitol 6-phosphate
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?
mannitol 1-phosphate + NAD+
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at 1-5% of reaction with sorbitol 6-phosphate
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-
?
D-sorbitol 6-phosphate + NAD+
the enzyme is much faster at oxidizing D-sorbitol 6-phosphate than in reducing D-fructose 6-phosphate, however, equilibrium analysis reveals that only part of the D-sorbitol 6-phosphate present in the in vitro environment is converted into D-fructose 6-phosphate
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-
r
D-fructose 6-phosphate + NADH + H+
D-sorbitol 6-phosphate + NAD+
the enzyme is much faster at oxidizing D-sorbitol 6-phosphate than in reducing D-fructose 6-phosphate, however, equilibrium analysis reveals that only part of the D-sorbitol 6-phosphate present in the in vitro environment is converted into D-fructose 6-phosphate
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-
r
D-fructose 6-phosphate + NADH + H+
D-sorbitol 6-phosphate + NAD+
AAV45891.1
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-
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?
D-fructose 6-phosphate + NADH + H+
D-sorbitol 6-phosphate + NAD+
AAV45891.1
the recombinant enzyme (HmS6PDH) has no activity to glucose or sorbitol
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-
?
D-fructose 6-phosphate + NADH + H+
D-sorbitol 6-phosphate + NAD+
AAV45891.1
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?
D-fructose 6-phosphate + NADH + H+
D-sorbitol 6-phosphate + NAD+
AAV45891.1
the recombinant enzyme (HmS6PDH) has no activity to glucose or sorbitol
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-
?
D-fructose 6-phosphate + NADH + H+
D-sorbitol 6-phosphate + NAD+
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sorbitol is not detected when Stl6PDH is not overexpressed
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?
D-fructose 6-phosphate + NADH + H+
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?
D-sorbitol 6-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
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high specificity for NAD+
high specificity for D-fructose 6-phosphate
r
D-sorbitol 6-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
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equilibrium far on the side of sorbitol 6-phosphate formation
high specificity for D-fructose 6-phosphate
r
D-sorbitol 6-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
high specificity for D-sorbitol 6-phosphate
high specificity for D-fructose 6-phosphate
r
D-sorbitol 6-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
in the plant pathogen Erwinia amylovora the enzyme (S6PDH, SrlD) is used by the bacterium to utilize sorbitol, which is used for carbohydrate transport in the host plants belonging to the Amygdaloideae subfamily (e.g., apple, pear, and quince)
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?
D-sorbitol 6-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
the enzyme is much faster at oxidizing D-sorbitol 6-phosphate than in reducing D-fructose 6-phosphate, however, equilibrium analysis reveals that only part of the D-sorbitol 6-phosphate present in the in vitro environment is converted into D-fructose 6-phosphate
-
-
r
D-sorbitol 6-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
in the plant pathogen Erwinia amylovora the enzyme (S6PDH, SrlD) is used by the bacterium to utilize sorbitol, which is used for carbohydrate transport in the host plants belonging to the Amygdaloideae subfamily (e.g., apple, pear, and quince)
-
-
?
D-sorbitol 6-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
the enzyme is much faster at oxidizing D-sorbitol 6-phosphate than in reducing D-fructose 6-phosphate, however, equilibrium analysis reveals that only part of the D-sorbitol 6-phosphate present in the in vitro environment is converted into D-fructose 6-phosphate
-
-
r
D-sorbitol 6-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
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-
-
?
D-sorbitol 6-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
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high specificity for NAD+
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-
?
D-sorbitol 6-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
high specificity for D-sorbitol 6-phosphate
-
-
?
D-sorbitol 6-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
high specificity for NAD+
-
-
?
D-sorbitol 6-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
high specificity for D-sorbitol 6-phosphate
-
-
?
D-sorbitol 6-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
high specificity for NAD+
-
-
r
D-sorbitol 6-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
high specificity for D-sorbitol 6-phosphate
-
r
D-sorbitol 6-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
high specificity for D-sorbitol 6-phosphate
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-
r
D-sorbitol 6-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
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-
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-
?
D-sorbitol 6-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
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hexitol catabolic enzyme
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?
D-sorbitol 6-phosphate + NADP+
D-fructose 6-phosphate + NADPH + H+
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key enzyme in the regulation of the sorbitol/sucrose ratio in apple leaves
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