1.1.1.11: D-arabinitol 4-dehydrogenase

This is an abbreviated version!
For detailed information about D-arabinitol 4-dehydrogenase, go to the full flat file.

Reaction

Synonyms

aArDH, arabitol dehydrogenase, ArDH, D-arabitol dehydrogenase, D-xylulose-forming D-arabitol dehydrogenase, dehydrogenase, D-arabinitol, NAD-dependent D-arabitol dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.11 D-arabinitol 4-dehydrogenase

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Results	in table
1	Activating Compound
105	AA Sequence
5	Application
1	CAS Registry Number
9	Cloned(Commentary)
24	Cofactor
2	Expression
2	General Information
2	General Stability
6	Inhibitors
6	kcat/KM [mM/s]
29	KM Value [mM]
5	Metals/Ions
15	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
43	Organism
6	Pathway
9	pH Optimum
5	pH Range
2	pH Stability
2	pI Value
1	Protein Variants
7	Purification (Commentary)
1	Reaction
3	Reaction Type
18	Reference
33	Specific Activity [micromol/min/mg]
5	Storage Stability
49	Substrates and Products (Substrate)
10	Subunits
12	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
12	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.1.1.11 - D-arabinitol 4-dehydrogenase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

D-arabinitol + NAD+

D-ribulose + NADH + H+

5 entries

D-arabinitol + NAD+

D-xylulose + NADH + H+

11 entries

D-arabitol + NAD+

D-xylulose + NADH + H+

2 entries

D-arabitol + NADP+

D-xylulose + NADPH + H+

Gluconobacter sp. JX-05

A0A2K9VPX3

-

760713

-

-

r

D-fructose + NADH + H+

D-mannitol + NAD+

Gluconobacter oxydans

Q308C1

-

701082

-

-

?

D-glucitol + NAD+

?

Scheffersomyces stipitis

-

recombinant protein from Saccharomyces cerevisiae and enzyme from Pichia stipitis

285754

-

-

?

D-mannitol + NAD+

D-fructose + NADH + H+

4 entries

D-ribulose + NADH + H+

D-arabinitol + NAD+

Saccharomyces cerevisiae

-

-

740490

-

-

?

D-sorbitol + NAD+

L-sorbose + NADH + H+

Gluconobacter oxydans

Q308C1

-

701082

-

-

?

D-sorbitol + NAD+

sorbose + NADH + H+

Gluconobacter sp. JX-05

A0A2K9VPX3

10.3% activity with D-sorbitol compared to D-arabitol

760713

-

-

r

D-xylulose + NADH + H+

D-arabitol + NAD+

Gluconobacter oxydans

Q308C1

-

701082

-

-

r

ethanol + NAD+

acetaldehyde + NADH + H+

2 entries

Galactitol + NAD+

?

3 entries

glycerol + NAD+

dihydroxyacetone + NADH + H+

2 entries

L-Xylulose + NADH

?

Candida tropicalis

-

3% activity

9566

-

-

?

meso-erythritol + NAD+

? + NADH + H+

Gluconobacter oxydans

Q308C1

-

701082

-

-

?

meso-erythritol + NAD+

L-erythrose + NADH + H+

Gluconobacter sp. JX-05

A0A2K9VPX3

5.3% activity with D-sorbitol compared to D-arabitol

760713

-

-

?

ribitol + NAD+

D-ribulose + NADH + H+

Gluconobacter oxydans

Q308C1

-

701082

-

-

?

Xylitol + NAD+

?

3 entries

xylitol + NAD+

D-xylulose + NADH + H+

2 entries

additional information

?

-

6 entries

D-arabinitol + NAD+

D-ribulose + NADH + H+

Candida albicans

-

-

9565

-

9565

?

D-arabinitol + NAD+

D-ribulose + NADH + H+

Candida albicans B331

-

-

9565

-

9565

?

D-arabinitol + NAD+

D-ribulose + NADH + H+

Candida tropicalis

-

-

9566

-

9566

?

D-arabinitol + NAD+

D-ribulose + NADH + H+

Candida tropicalis

-

-

285753

-

285753

?

D-arabinitol + NAD+

D-ribulose + NADH + H+

Scheffersomyces stipitis

-

recombinant protein from Saccharomyces cerevisiae

285754

-

285754

?

D-arabinitol + NAD+

D-xylulose + NADH + H+

Gluconobacter oxydans

Q308C1

-

701082

-

-

r

D-arabinitol + NAD+

D-xylulose + NADH + H+

Gluconobacter sp. JX-05

A0A2K9VPX3

-

760713

-

-

r

D-arabinitol + NAD+

D-xylulose + NADH + H+

Klebsiella aerogenes

-

-

285747

-

-

?

D-arabinitol + NAD+

D-xylulose + NADH + H+

Klebsiella aerogenes

-

-

285748

-

285748

?

D-arabinitol + NAD+

D-xylulose + NADH + H+

Klebsiella aerogenes

-

-

285749

-

-

r

D-arabinitol + NAD+

D-xylulose + NADH + H+

Klebsiella aerogenes

-

-

285750

-

285750

r

D-arabinitol + NAD+

D-xylulose + NADH + H+

Klebsiella aerogenes

-

-

285751

-

285751

r

D-arabinitol + NAD+

D-xylulose + NADH + H+

Klebsiella aerogenes PRL-R3

-

-

285748

-

285748

?

D-arabinitol + NAD+

D-xylulose + NADH + H+

Klebsiella aerogenes PRL-R3

-

-

285749

-

-

r

D-arabinitol + NAD+

D-xylulose + NADH + H+

Klebsiella aerogenes PRL-R3

-

-

285750

-

285750

r

D-arabinitol + NAD+

D-xylulose + NADH + H+

Scheffersomyces stipitis

-

D-arabitol i.e. D-arabinitol

285754

-

285754

?

D-arabitol + NAD+

D-xylulose + NADH + H+

Gluconobacter oxydans

Q308C1

is the optimal substrate for aArDH

701082

-

-

r

D-arabitol + NAD+

D-xylulose + NADH + H+

Gluconobacter sp. JX-05

A0A2K9VPX3

best substrates in both reaction directions

760713

-

-

r

D-mannitol + NAD+

D-fructose + NADH + H+

Gluconobacter oxydans

Q308C1

-

701082

-

-

?

D-mannitol + NAD+

D-fructose + NADH + H+

Gluconobacter sp. JX-05

A0A2K9VPX3

30.5% and 54.8% activity with D-mannitol and D-fructose compared to D-arabitol and D-xylulose, respectively

760713

-

-

r

D-mannitol + NAD+

D-fructose + NADH + H+

Klebsiella aerogenes

-

-

285747

-

-

?

D-mannitol + NAD+

D-fructose + NADH + H+

Klebsiella aerogenes

-

-

285751

-

285751

?

ethanol + NAD+

acetaldehyde + NADH + H+

Gluconobacter oxydans

Q308C1

-

701082

-

-

?

ethanol + NAD+

acetaldehyde + NADH + H+

Gluconobacter sp. JX-05

A0A2K9VPX3

1.9% activity with D-sorbitol compared to D-arabitol

760713

-

-

?

Galactitol + NAD+

?

Candida tropicalis

-

-

285753

-

-

?

Galactitol + NAD+

?

Candida tropicalis

-

1.6% activity

9566

-

-

?

Galactitol + NAD+

?

Scheffersomyces stipitis

-

recombinant protein from Saccharomyces cerevisiae

285754

-

-

?

glycerol + NAD+

dihydroxyacetone + NADH + H+

Gluconobacter oxydans

Q308C1

-

701082

-

-

?

glycerol + NAD+

dihydroxyacetone + NADH + H+

Gluconobacter sp. JX-05

A0A2K9VPX3

6.2% activity with D-sorbitol compared to D-arabitol

760713

-

-

?

Xylitol + NAD+

?

Candida tropicalis

-

-

285753

-

-

?

Xylitol + NAD+

?

Candida tropicalis

-

5% activity

9566

-

-

?

Xylitol + NAD+

?

Scheffersomyces stipitis

-

recombinant protein from Saccharomyces cerevisiae and enzyme from Pichia stipitis

285754

-

-

?

xylitol + NAD+

D-xylulose + NADH + H+

Gluconobacter oxydans

Q308C1

-

701082

-

-

?

xylitol + NAD+

D-xylulose + NADH + H+

Gluconobacter sp. JX-05

A0A2K9VPX3

8.8% activity with D-sorbitol compared to D-arabitol

760713

-

-

r

additional information

?

-

Candida tropicalis

-

no activity with D-mannitol

9566

-

-

?

additional information

?

-

Gluconobacter oxydans

-

both purified native and recombinant aArDH do not accept L-arabitol as substrate

701082

-

-

?

additional information

?

-

Gluconobacter oxydans

Q308C1

both purified native and recombinant aArDH do not accept L-arabitol as substrate

701082

-

-

?

additional information

?

-

Gluconobacter oxydans

-

no substrate: L-arabinitol

701082

-

-

?

additional information

?

-

Gluconobacter oxydans

Q308C1

no substrate: L-arabinitol

701082

-

-

?

additional information

?

-

Scheffersomyces stipitis

-

D-arabinitol dehydrogenases (ArDH) from fungi and yeast oxidize D-arabinitol to D-ribulose, whereas bacterial ArDH oxidizes D-arabinitol to D-xylulose

285754

-

-

?