1.1.1.103: L-threonine 3-dehydrogenase
This is an abbreviated version!
For detailed information about L-threonine 3-dehydrogenase, go to the full flat file.
Reaction
Synonyms
CLOST_1621, L-ThrDH, L-threonine dehydrogenase, More, orf382, TDG, TDH, Thr dehydrogenase, ThrDH, threonine 3-dehydrogenase, threonine dehydrogenase
ECTree
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yuan, J.H.; austic, R.E.
Characterization of hepatic L-threonine dehydrogenase of chicken
Comp. Biochem. Physiol. B
130
65-73
2001
Gallus gallus
Johnson, A.R.; Chen, Y.W.; Dekker, E.E.
Investigation of a catalytic zinc binding site in Escherichia coli L-threonine dehydrogenase by site-directed mutagenesis of cysteine-38
Arch. Biochem. Biophys.
358
211-221
1998
Escherichia coli K-12
Marcus, J.P.; Dekker, E.E.
Identification of a second active site residue in Escherichia coli L-threonine dehydrogenase: methylation of histidin-90 with methyl p-nitrobenzenesulfonate
Arch. Biochem. Biophys.
316
413-420
1995
Escherichia coli K-12
Chen, Y.W.; Dekker, E.E.; Somerville, R.L.
Functional analysis of E. coli threonine dehydrogenase by means of mutant isolation and characterization
Biochim. Biophys. Acta
1253
208-214
1995
Escherichia coli K-12
Kao, Y.C.; Davis, L.
Purification and structural characterization of porcine L-threonine dehydrogenase
Protein Expr. Purif.
5
423-431
1994
Sus scrofa
Marcus, J.P.; Dekker, E.E.
Threonine formation via the coupled activity of 2-amino-3-ketobutyrate coenzyme A lyase and threonine dehydrogenase
J. Bacteriol.
175
6505-6511
1993
Escherichia coli K-12
Pagani, R.; Leoncini, R.; Righi, S.; Guerranti, R.; Lazzerretti, L.; Marinello, E.
Mitochondrial L-threonine dehydrogenase
Biochem. Soc. Trans.
20
379
1992
Rattus norvegicus
-
Pagani, R.; Guerranti, R.; Right, S.; Leoncini, R.; Vannoni, D.; Marinello, E.
Rat liver L-threonine dehydrogenase
Biochem. Soc. Trans.
20
24
1991
Bos taurus, Rattus norvegicus
-
Epperly, B.R.; Dekker, E.E.
L-Threonine dehydrogenase from Escherichia coli
J. Biol. Chem.
266
6086-6092
1991
Escherichia coli K-12
Craig, P.A.; Dekker, E.E.
The sulfhydryl content of L-threonine dehydrogenase from Escherichia coli K-12: relation to catalytic activity and Mn2+ activation
Biochim. Biophys. Acta
1037
30-38
1990
Escherichia coli K-12
Aronson, B.D.; Somerville, R.L.; Epperly, B.R.; Dekker, E.E.
The primary structure of Escherichia coli L-threonine dehydrogenase
J. Biol. Chem.
264
5226-5232
1989
Escherichia coli K-12
Craig, P.A.; Dekker, E.E.
Cd2+ activation of L-threonine dehydrogenase from Escherichia coli K-12
Biochim. Biophys. Acta
957
222-229
1988
Escherichia coli K-12
Tressel, T.; Thompson, R.; Zieske, L.R.; Menendez, M.I.T.S.; Davis, L.
Interaction between L-threonine dehydrogenase and aminoacetone synthetase and mechanism of aminoacetone production
J. Biol. Chem.
261
16428-16437
1986
Sus scrofa
Craig, P.A.; Dekker, E.E.
L-Threonine dehydrogenase from Escherichia coli K-12: thiol-dependent activation by Mn2+
Biochemistry
25
1870-1876
1986
Escherichia coli K-12
Ray, M.; Ray, S.
L-Threonine dehydrogenase from goat liver
J. Biol. Chem.
260
5913-5918
1985
Capra hircus
Boylan, S.A.; Dekker, E.E.
L-threonine dehydrogenase
J. Biol. Chem.
256
1809-1815
1981
Escherichia coli K-12
Aoyama, Y.; Motokawa, Y.
L-Threonine dehydrogenase of chicken liver
J. Biol. Chem.
256
12367-12373
1981
Gallus gallus
Boylan, S.A.; Dekker, E.E.
L-Threonine dehydrogenase of Escherichia coli K-12
Biochem. Biophys. Res. Commun.
85
190-197
1978
Escherichia coli K-12
McGilvray, D.; Morris, J.G.
L-Threonine dehydrogenase (Arthrobacter)
Methods Enzymol.
17B
580-584
1971
Arthrobacter sp.
-
Green, M.L.; Elliott, W.H.
The enzymatic formation of aminoacetone from threonine and its further metabolism
biochem. J.
92
537-548
1964
Gallus gallus, Oryctolagus cuniculus, Staphylococcus aureus, Rattus norvegicus, Sus scrofa
Hartshorne, D.; Greenberg, D.M.
Studies on liver threonine dehydrogenase
Arch. Biochem. Biophys.
105
173-178
1964
Lithobates catesbeianus
Akagi, S.; Sato, K.; Ohmori, S.
Threonine metabolism in Japanese quail liver
Amino Acids
26
235-242
2004
Coturnix japonica, Rattus norvegicus
Edgar, A.J.
Molecular cloning and tissue distribution of mammalian L-threonine 3-dehydrogenases
BMC Biochem.
3
19
2002
Mus musculus (Q8K3F7), Mus musculus, Sus scrofa (Q8MIR0), Sus scrofa
Edgar, A.J.
The human L-threonine 3-dehydrogenase gene is an expressed pseudogene
BMC Genet.
3
18
2002
Homo sapiens
Kazuoka, T.; Takigawa, S.; Arakawa, N.; Hizukuri, Y.; Muraoka, I.; Oikawa, T.; Soda, K.
Novel psychrophilic and thermolabile L-threonine dehydrogenase from psychrophilic Cytophaga sp. strain KUC-1
J. Bacteriol.
185
4483-4489
2003
Cytophaga sp. (Q8KZM4), Cytophaga sp., Cytophaga sp. KUC-1 (Q8KZM4)
Higashi, N.; Matsuura, T.; Nakagawa, A.; Ishikawa, K.
Crystallization and preliminary X-ray analysis of hyperthermophilic L-threonine dehydrogenase from the archaeon Pyrococcus horikoshii
Acta crystallogr. Sect. F
61
432-434
2005
Pyrococcus horikoshii
Le Floch, N.; Seve, B.
Catabolism through the threonine dehydrogenase pathway does not account for the high first-pass extraction rate of dietary threonine by the portal drained viscera in pigs
Br. J. Nutr.
93
447-456
2005
Sus scrofa
Shimizu, Y.; Sakuraba, H.; Kawakami, R.; Goda, S.; Kawarabayasi, Y.; Ohshima, T.
L-Threonine dehydrogenase from the hyperthermophilic archaeon Pyrococcus horikoshii OT3: gene cloning and enzymatic characterization
Extremophiles
9
317-324
2005
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Machielsen, R.; van der Oost, J.
Production and characterization of a thermostable L-threonine dehydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus
FEBS J.
273
2722-2729
2006
Pyrococcus furiosus
Higashi, N.; Fukada, H.; Ishikawa, K.
Kinetic study of thermostable L-threonine dehydrogenase from an archaeon Pyrococcus horikoshii
J. Biosci. Bioeng.
99
175-180
2005
Pyrococcus horikoshii
Higashi, N.; Tanimoto, K.; Nishioka, M.; Ishikawa, K.; Taya, M.
Investigating a catalytic mechanism of hyperthermophilic L-threonine dehydrogenase from Pyrococcus horikoshii
J. Biochem.
144
77-85
2008
Pyrococcus horikoshii (O58389), Pyrococcus horikoshii
Ishikawa, K.; Higashi, N.; Nakamura, T.; Matsuura, T.; Nakagawa, A.
The first crystal structure of L-threonine dehydrogenase
J. Mol. Biol.
366
857-867
2007
Pyrococcus horikoshii (O58389), Pyrococcus horikoshii
Bowyer, A.; Mikolajek, H.; Wright, J.N.; Coker, A.; Erskine, P.T.; Cooper, J.B.; Bashir, Q.; Rashid, N.; Jamil, F.; Akhtar, M.
Crystallization and preliminary X-ray diffraction analysis of L-threonine dehydrogenase (TDH) from the hyperthermophilic archaeon Thermococcus kodakaraensis
Acta Crystallogr. Sect. F
64
828-830
2008
Thermococcus kodakarensis (Q5JI69), Thermococcus kodakarensis
Bao, Y.; Xie, H.; Shan, J.; Jiang, R.; Zhang, Y.; Guo, L.; Zhang, R.; Li, Y.
Biochemical characteristics and function of a threonine dehydrogenase encoded by ste11 in Ebosin biosynthesis of Streptomyces sp. 139
J. Appl. Microbiol.
106
1140-1146
2009
Streptomyces sp. 139
Bashir, Q.; Rashid, N.; Jamil, F.; Imanaka, T.; Akhtar, M.
Highly thermostable L-threonine dehydrogenase from the hyperthermophilic archaeon Thermococcus kodakaraensis
J. Biochem.
146
95-102
2009
Thermococcus kodakarensis KOD1
Bowyer, A.; Mikolajek, H.; Stuart, J.W.; Wood, S.P.; Jamil, F.; Rashid, N.; Akhtar, M.; Cooper, J.B.
Structure and function of the l-threonine dehydrogenase (TkTDH) from the hyperthermophilic archaeon Thermococcus kodakaraensis
J. Struct. Biol.
168
294-304
2009
Thermococcus kodakarensis (Q5JI69), Thermococcus kodakarensis
Lee, J.H.; Sung, B.H.; Kim, M.S.; Blattner, F.R.; Yoon, B.H.; Kim, J.H.; Kim, S.C.
Metabolic engineering of a reduced-genome strain of Escherichia coli for L-threonine production
Microb. Cell Fact.
8
02
2009
Escherichia coli, Escherichia coli MDS42
Wang, J.; Alexander, P.; Wu, L.; Hammer, R.; Cleaver, O.; McKnight, S.L.
Dependence of mouse embryonic stem cells on threonine catabolism
Science
325
435-439
2009
Mus musculus
Ueatrongchit, T.; Asano, Y.
Highly selective L-threonine 3-dehydrogenase from Cupriavidus necator and its use in determination of L-threonine
Anal. Biochem.
410
44-56
2011
Cupriavidus necator (E5RQ20), Cupriavidus necator, Cupriavidus necator NBRC 102504 (E5RQ20), Cupriavidus necator NBRC 102504
Yoneda, K.; Sakuraba, H.; Araki, T.; Ohshima, T.
Crystal structure of binary and ternary complexes of archaeal UDP-galactose 4-epimerase-like L-threonine dehydrogenase from Thermoplasma volcanium
J. Biol. Chem.
287
12966-12974
2012
Thermoplasma volcanium
Han, C.; Gu, H.; Wang, J.; Lu, W.; Mei, Y.; Wu, M.
Regulation of L-threonine dehydrogenase in somatic cell reprogramming
Stem Cells
31
953-965
2013
Mus musculus
Wagner, M.; Andreesen, J.R.
Purification and characterization of threonine dehydrogenase from Clostridium sticklandi
Arch. Microbiol.
163
286-290
1995
Acetoanaerobium sticklandii (E3PS87), Acetoanaerobium sticklandii, Acetoanaerobium sticklandii DSM 519 (E3PS87)
Lee, C.; Cho, I.; Lee, Y.; Son, Y.; Kwak, I.; Ahn, Y.; Kim, S.; An, W.
Effects of dietary levels of glycine, threonine and protein on threonine efficiency and threonine dehydrogenase activity in hepatic mitochondria of chicks
Asian-australas. J. Anim. Sci.
27
69-76
2014
Gallus gallus
Nakano, S.; Okazaki, S.; Tokiwa, H.; Asano, Y.
Binding of NAD+ and L-threonine induces stepwise structural and flexibility changes in Cupriavidus necator L-threonine dehydrogenase
J. Biol. Chem.
289
10445-10454
2014
Cupriavidus necator
Ma, F.; Wang, T.; Ma, X.; Wang, P.
Identification and characterization of protein encoded by orf382 as L-threonine dehydrogenase
J. Microbiol. Biotechnol.
24
748-755
2014
Escherichia coli (P07913), Escherichia coli
He, C.; Huang, X.; Liu, Y.; Li, F.; Yang, Y.; Tao, H.; Han, C.; Zhao, C.; Xiao, Y.; Shi, Y.
Structural insights on mouse L-threonine dehydrogenase: A regulatory role of Arg180 in catalysis
J. Struct. Biol.
192
510-518
2015
Mus musculus (Q8K3F7), Mus musculus
Desjardins, M.; Mak, W.S.; OBrien, T.E.; Carlin, D.A.; Tantillo, D.J.; Siegel, J.B.
Systematic functional analysis of active-site residues in l-threonine dehydrogenase from Thermoplasma volcanium
ACS Omega
2
3308-3314
2017
Thermoplasma volcanium (Q97BK3), Thermoplasma volcanium, Thermoplasma volcanium ATCC 51530 (Q97BK3)
Adjogatse, E.; Erskine, P.; Wells, S.A.; Kelly, J.M.; Wilden, J.D.; Chan, A.W.E.; Selwood, D.; Coker, A.; Wood, S.; Cooper, J.B.
Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations
Acta Crystallogr. Sect. D
74
861-876
2018
Trypanosoma brucei (Q7YW97)
Fujimoto, H.; Fujita, N.; Takada, R.
Effects of a rice diet and phytase addition on growth performance, tissue weights, phosphorus and nitrogen retention, and on liver threonine dehydrogenase, malic enzyme and fatty acid synthase activities in broiler chicks
Anim. Sci. J.
89
770-776
2018
Gallus gallus, Gallus gallus ROSS 308
Zhang, L.; Cao, Y.; Tong, J.; Xu, Y.
An alkylpyrazine synthesis mechanism involving L-threonine-3-dehydrogenase describes the production of 2,5-dimethylpyrazine and 2,3,5-trimethylpyrazine by Bacillus subtilis
Appl. Environ. Microbiol.
85
e01807-19
2019
Bacillus subtilis (O31776), Bacillus subtilis 168 (O31776)
Motoyama, T.; Nakano, S.; Yamamoto, Y.; Tokiwa, H.; Asano, Y.; Ito, S.
Product release mechanism associated with structural changes in monomeric L-threonine 3-dehydrogenase
Biochemistry
56
5758-5770
2017
uncultured archaeon (D6PBM7)
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