1.1.1.102: 3-dehydrosphinganine reductase
This is an abbreviated version!
For detailed information about 3-dehydrosphinganine reductase, go to the full flat file.
Word Map on EC 1.1.1.102
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1.1.1.102
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sphingolipids
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ceramide
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nadph-dependent
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phytosphingosine
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sphingomyelin
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inositolphosphorylceramide
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palmitoyl-coa
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food industry
- 1.1.1.102
- sphingolipids
- ceramide
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nadph-dependent
- phytosphingosine
- sphingomyelin
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inositolphosphorylceramide
- palmitoyl-coa
- food industry
Reaction
Synonyms
3-KDS reductase, 3-ketodihydrosphingosine reductase, 3-ketosphinganine reductase, 3-oxosphinganine reductase, 3-oxosphinganine:NADPH oxidoreductase, 3KDSR, D-3-dehydrosphinganine reductase, D-3-oxosphinganine reductase, D-3-oxosphinganine:B-NADPH oxidoreductase, DSR, FVT-1, Fvt1, h-FTV-1, KDS reductase, Ksr1p, KsrA, m-FTV-1, More, TSC10, TSC10A, Tsc10p
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Substrates Products
Substrates Products on EC 1.1.1.102 - 3-dehydrosphinganine reductase
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REACTION DIAGRAM
(S)-2-amino-1-hydroxyeicosane-3-one + NADPH
(S)-2-amino-1-(R)-3-dihydroxyeicosane + NADP+
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slower reduced than (S)-2-amino-1-hydroxyoctadecane-3-one
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?
(S)-2-amino-1-hydroxyoctadecan-3-one + NADPH
(S)-2-amino-1-(R)-3-dihydroxyoctadecane + NADP+
2-amino-1-hydroxyoctadecan-3-one + NADPH
2-amino-1,3-dihydroxyoctadecane + NADP+
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?
3-oxosphinganine + NADPH + H+
D-erythro-dihydrosphingosine + L-threo-dihydrosphingosine + NADP+
(S)-2-amino-1-(R)-3-dihydroxyoctadecane + NADP+
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-
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?
(S)-2-amino-1-hydroxyoctadecan-3-one + NADPH
(S)-2-amino-1-(R)-3-dihydroxyoctadecane + NADP+
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?
(S)-2-amino-1-hydroxyoctadecan-3-one + NADPH
(S)-2-amino-1-(R)-3-dihydroxyoctadecane + NADP+
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enzyme acts at the cytoplasmic side of endoplasmic reticulum
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?
(2S,3R)-2-aminooctadecane-1,3-diol + NADP+
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?
2-amino-1-hydroxyoctadecan-3-one + NADPH
(2S,3R)-2-aminooctadecane-1,3-diol + NADP+
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?
3-dehydrosphinganine + NADPH
sphinganine + NADP+
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the enzyme is not essential for cell viability, but enzyme-deficient mutants produce lower levels of inositolphosphorylceramides
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?
3-dehydrosphinganine + NADPH
sphinganine + NADP+
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C18 substrate, molecular modeling of substrate binding, overview
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3-dehydrosphinganine + NADPH
sphinganine + NADP+
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the enzyme catalyzes an early step in the sphingolipid biosynthesis, overview
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?
D-erythro-dihydrosphingosine + L-threo-dihydrosphingosine + NADP+
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?
3-oxosphinganine + NADPH + H+
D-erythro-dihydrosphingosine + L-threo-dihydrosphingosine + NADP+
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?
3-oxosphinganine + NADPH + H+
D-erythro-dihydrosphingosine + L-threo-dihydrosphingosine + NADP+
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?
additional information
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FVT1 is able to support growth of tsc10DELTA mutant cells at 26°C, but not at 37°C
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?