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1.1.1.10: L-xylulose reductase

This is an abbreviated version!
For detailed information about L-xylulose reductase, go to the full flat file.

Word Map on EC 1.1.1.10

Reaction

xylitol
+
NADP+
=
L-xylulose
+
NADPH
+
H+

Synonyms

DCXR, dicarbonyl/L-xylulose reductase, L-xylulose reductase, LXR, LXR3, More, NAD(P)H-dependent xylose reductase, NADP(+)-dependent xylitol dehydrogenase, NADP(H)-preferring xylitol dehydrogenase, NADP+-dependent xylitol dehydrogenase, NADP+-linked xylitol dehydrogenase, P31h, P34H, reductase, L-xylulose, RpLXR, Rplxr3, XDH, XR, XylB, xylitol dehydrogenase, xylose reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.10 L-xylulose reductase

Reference

Reference on EC 1.1.1.10 - L-xylulose reductase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hickman, J.; Ashwell, G.
A sensitive and stereospecific enzymatic assay for xylulose
J. Biol. Chem.
234
758-761
1959
Cavia porcellus
Manually annotated by BRENDA team
Alizade, M.A.; Brendel, K.; Gaede, K.
Chirality of xylitol-oxidizing enzymes from mammalian liver
FEBS Lett.
67
41-44
1976
Cavia porcellus
Manually annotated by BRENDA team
Doten, R.C.; Mortlock, R.P.
Inducible xylitol dehydrogenases in enteric bacteria
J. Bacteriol.
162
845-848
1985
Erwinia sp., Erwinia sp. 4D2P
Manually annotated by BRENDA team
Doten, R.C.; Mortlock, R.P.
Characterization of xylitol-utilizing mutants of Erwinia uredovora
J. Bacteriol.
161
529-533
1985
Pantoea ananatis
Manually annotated by BRENDA team
Lowe, C.R.; Mosbach, K.; Dean, P.D.G.
Some applications of insolubilised cofactors to the purification of pyridine nucleotide-dependent dehydrogenases
Biochem. Biophys. Res. Commun.
48
1004-1010
1972
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Hollmann, S.; Touster, O.
The L-xylulose-xylitol enzyme and other polyol dehydrogenases of guinea pig liver mitochondria
J. Biol. Chem.
225
87-102
1957
Cavia porcellus
Manually annotated by BRENDA team
Touster, O.; Reynolds, V.H.; Hutcheson, R.M.
The reduction of L-xylulose to xylitol by guinea pig liver mitochondria
J. Biol. Chem.
221
697-709
1954
Cavia porcellus
Manually annotated by BRENDA team
Witteveen, C.F.B.; Weber, F.; Busink, R.; Visser, J.
Isolation and characterization of two xylitol dehydrogenases from Aspergillus niger
Microbiology
140
1679-1685
1994
Aspergillus niger
-
Manually annotated by BRENDA team
Metzger, M.H.; Hollenberg, C.P.
Amino acid substitutions in the yeast Pichia stipitis xylitol dehydrogenase coenzyme-binding domain affect the coenzyme specificity
Eur. J. Biochem.
228
50-54
1995
Scheffersomyces stipitis
Manually annotated by BRENDA team
Ishikura, S.; Isaji, T.; Usami, N.; Kitahara, K.; Nakagawa, J.; Hara, A.
Molecular cloning, expression and tissue distribution of hamster diacetyl reductase. Identity with L-xylulose reductase
Chem. Biol. Interact.
130-132
879-889
2001
Cricetinae
Manually annotated by BRENDA team
Ishikura, S.; Usami, N.; El-Kabbani, O.; Hara, A.
Structural determinant for cold inactivation of rodent L-xylulose reductase
Biochem. Biophys. Res. Commun.
308
68-72
2003
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Carbone, V.; Darmanin, C.; Ishikura, S.; Hara, A.; El-Kabbani, O.
Structure-based design of inhibitors of human L-xylulose reductase modelled into the active site of the enzyme
Bioorg. Med. Chem. Lett.
13
1469-1474
2003
Homo sapiens
Manually annotated by BRENDA team
Ishikura, S.; Isaji, T.; Usami, N.; Nakagawa, J.; El-Kabbani, O.; Hara, A.
Identification of amino acid residues involved in substrate recognition of L-xylulose reductase by site-directed mutagenesis
Chem. Biol. Interact.
143-144
543-550
2003
Rattus norvegicus
Manually annotated by BRENDA team
Nakagawa, J.; Ishikura, S.; Asami, J.; Isaji, T.; Usami, N.; Hara, A.; Sakurai, T.; Tsuritani, K.; Oda, K.; Takahashi, M.; Yoshimoto, M.; Otsuka, N.; Kitamura, K.
Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney
J. Biol. Chem.
277
17888-17891
2002
Cavia porcellus (Q920N9), Cavia porcellus, Homo sapiens (Q7Z4W1), Homo sapiens, Mesocricetus auratus (Q91XV4), Mus musculus (Q91X52), Mus musculus, Rattus norvegicus (Q920P0)
Manually annotated by BRENDA team
Verho, R.; Putkonen, M.; Londesborough, J.; Penttilä, M.; Richard, P.
A novel NADH-linked L-xylulose reductase in the L-arabinose catabolic pathway of yeast
J. Biol. Chem.
279
14746-14751
2004
Ambrosiozyma monospora (Q70FD1), Ambrosiozyma monospora
Manually annotated by BRENDA team
Saint-Cyr, A.; Legare, C.; Frenette, G.; Gaudreault, C.; Sullivan, R.
P26h and dicarbonyl/L-xylulose reductase are two distinct proteins present in the hamster epididymis
Mol. Reprod. Dev.
69
137-145
2004
Mesocricetus auratus
Manually annotated by BRENDA team
El-Kabbani, O.; Ishikura, S.; Darmanin, C.; Carbone, V.; Chung, R.P.T.; Usami, N.; Hara, A.
Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis
Proteins
55
724-732
2004
Homo sapiens (Q7Z4W1), Homo sapiens
Manually annotated by BRENDA team
Matsunaga, T.; Shintani, S.; Hara, A.
Multiplicity of mammalian reductases for xenobiotic carbonyl compounds
Drug Metab. Pharmacokinet.
21
1-18
2006
Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Sudo, T.; Ishii, A.; Asami, J.; Uematsu, Y.; Saitoh, M.; Nakamura, A.; Tada, N.; Ohnuki, T.; Komurasaki, T.; Nakagawa, J.
Transgenic mice over-expressing dicarbonyl/L-xylulose reductase gene crossed with KK-A(y) diabetic model mice: an animal model for the metabolism of renal carbonyl compounds
Exp. Anim.
54
385-394
2005
Mus musculus
Manually annotated by BRENDA team
El-Kabbani, O.; Carbone, V.; Darmanin, C.; Ishikura, S.; Hara, A.
Structure of the tetrameric form of human L-xylulose reductase: probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis
Proteins
60
424-432
2005
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Nair, N.; Zhao, H.
Biochemical characterization of an L-Xylulose reductase from Neurospora crassa
Appl. Environ. Microbiol.
73
2001-2004
2007
Neurospora crassa
Manually annotated by BRENDA team
Matsunaga, T.; Kamiya, T.; Sumi, D.; Kumagai, Y.; Kalyanaraman, B.; Hara, A.
L-Xylulose reductase is involved in 9,10-phenanthrenequinone-induced apoptosis in human T lymphoma cells
Free Radic. Biol. Med.
44
1191-1202
2008
Homo sapiens
Manually annotated by BRENDA team
Matsushika, A.; Watanabe, S.; Kodaki, T.; Makino, K.; Sawayama, S.
Bioethanol production from xylose by recombinant Saccharomyces cerevisiae expressing xylose reductase, NADP(+)-dependent xylitol dehydrogenase, and xylulokinase
J. Biosci. Bioeng.
105
296-299
2008
Scheffersomyces stipitis
Manually annotated by BRENDA team
Hou, J.; Shen, Y.; Li, X.P.; Bao, X.M.
Effect of the reversal of coenzyme specificity by expression of mutated Pichia stipitis xylitol dehydrogenase in recombinant Saccharomyces cerevisiae
Lett. Appl. Microbiol.
45
184-189
2007
Scheffersomyces stipitis
Manually annotated by BRENDA team
Matsushika, A.; Inoue, H.; Watanabe, S.; Kodaki, T.; Makino, K.; Sawayama, S.
Efficient bioethanol production by a recombinant flocculent Saccharomyces cerevisiae strain with a genome-integrated NADP+-dependent xylitol dehydrogenase gene
Appl. Environ. Microbiol.
75
3818-3822
2009
Scheffersomyces stipitis
Manually annotated by BRENDA team
Matsushika, A.; Watanabe, S.; Kodaki, T.; Makino, K.; Inoue, H.; Murakami, K.; Takimura, O.; Sawayama, S.
Expression of protein engineered NADP+-dependent xylitol dehydrogenase increases ethanol production from xylose in recombinant Saccharomyces cerevisiae
Appl. Microbiol. Biotechnol.
81
243-255
2008
Scheffersomyces stipitis
Manually annotated by BRENDA team
Hou, J.; Vemuri, G.N.; Bao, X.; Olsson, L.
Impact of overexpressing NADH kinase on glucose and xylose metabolism in recombinant xylose-utilizing Saccharomyces cerevisiae
Appl. Microbiol. Biotechnol.
82
909-919
2009
Scheffersomyces stipitis
Manually annotated by BRENDA team
Krahulec, S.; Klimacek, M.; Nidetzky, B.
Engineering of a matched pair of xylose reductase and xylitol dehydrogenase for xylose fermentation by Saccharomyces cerevisiae
Biotechnol. J.
4
684-694
2009
Yamadazyma tenuis
Manually annotated by BRENDA team
Zhao, H.T.; Endo, S.; Ishikura, S.; Chung, R.; Hogg, P.J.; Hara, A.; El-Kabbani, O.
Structure/function analysis of a critical disulfide bond in the active site of L-xylulose reductase
Cell. Mol. Life Sci.
66
1570-1579
2009
Homo sapiens (Q7Z4W1)
Manually annotated by BRENDA team
Branco, R.; dos Santos, J.; Sarrouh, B.; Rivaldi, J.; Pessoa Jr., A.; da Silva, S.
Profiles of xylose reductase, xylitol dehydrogenase and xylitol production under different oxygen transfer volumetric coefficient values
J. Chem. Technol. Biotechnol.
84
326-330
2009
Meyerozyma guilliermondii, Meyerozyma guilliermondii FTI
-
Manually annotated by BRENDA team
Gurpilhares, D.B.; Hasmann, F.A.; Pessoa, A.; Roberto, I.C.
The behavior of key enzymes of xylose metabolism on the xylitol production by Candida guilliermondii grown in hemicellulosic hydrolysate
J. Ind. Microbiol. Biotechnol.
36
87-93
2009
Meyerozyma guilliermondii
Manually annotated by BRENDA team
Mojzita, D.; Vuoristo, K.; Koivistoinen, O.M.; Penttilae, M.; Richard, P.
The true L-xylulose reductase of filamentous fungi identified in Aspergillus niger
FEBS Lett.
584
3540-3544
2010
Aspergillus niger
Manually annotated by BRENDA team
Metz, B.; Mojzita, D.; Herold, S.; Kubicek, C.P.; Richard, P.; Seiboth, B.
A novel L-xylulose reductase essential for L-arabinose catabolism in Trichoderma reesei
Biochemistry
52
2453-2460
2013
Trichoderma reesei (Q8NK50), Trichoderma reesei, Trichoderma reesei QM9414 (Q8NK50)
Manually annotated by BRENDA team
Son, l.e..T.; Ko, K.M.; Cho, J.H.; Singaravelu, G.; Chatterjee, I.; Choi, T.W.; Song, H.O.; Yu, J.R.; Park, B.J.; Lee, S.K.; Ahnn, J.
DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans
FEBS Lett.
585
1310-1316
2011
Caenorhabditis elegans (Q21929), Caenorhabditis elegans
Manually annotated by BRENDA team
Zheng, Y.; Yu, X.; Li, T.; Xiong, X.; Chen, S.
Induction of D-xylose uptake and expression of NAD(P)H-linked xylose reductase and NADP+-linked xylitol dehydrogenase in the oleaginous microalga Chlorella sorokiniana
Biotechnol. Biofuels
7
125
2014
Chlorella sorokiniana, Chlorella sorokiniana UTEX 1602
Manually annotated by BRENDA team
Zhang, B.; Zhang, J.; Wang, D.; Gao, X.; Sun, L.; Hong, J.
Data for rapid ethanol production at elevated temperatures by engineered thermotolerant Kluyveromyces marxianus via the NADP(H)-preferring xylose reductase-xylitol dehydrogenase pathway
Data Brief
5
179-186
2015
Kluyveromyces marxianus, Kluyveromyces marxianus YZJ088
Manually annotated by BRENDA team
Khattab, S.M.; Saimura, M.; Kodaki, T.
Boost in bioethanol production using recombinant Saccharomyces cerevisiae with mutated strictly NADPH-dependent xylose reductase and NADP+-dependent xylitol dehydrogenase
J. Biotechnol.
165
153-156
2013
Scheffersomyces stipitis
Manually annotated by BRENDA team
Yamasaki-Yashiki, S.; Komeda, H.; Hoshino, K.; Asano, Y.
Characterization and gene cloning of L-xylulose reductase involved in L-arabinose catabolism from the pentose-fermenting fungus Rhizomucor pusillus
Biosci. Biotechnol. Biochem.
81
1612-1618
2017
Rhizomucor pusillus (A0A0M4UR95), Rhizomucor pusillus, Rhizomucor pusillus NBRC 4578 (A0A0M4UR95), Rhizomucor pusillus NBRC 4578
Manually annotated by BRENDA team
Yuan, X.; Wang, J.; Lin, J.; Yang, L.; Wu, M.
Efficient production of xylitol by the integration of multiple copies of xylose reductase gene and the deletion of Embden-Meyerhof-Parnas pathway-associated genes to enhance NADPH regeneration in Escherichia coli
J. Ind. Microbiol. Biotechnol.
46
1061-1069
2019
Neurospora crassa (Q7SD67), Neurospora crassa, Neurospora crassa CBS 708.71 (Q7SD67), Neurospora crassa 74-OR23-1A (Q7SD67), Neurospora crassa DSM 1257 (Q7SD67), Neurospora crassa ATCC 24698 (Q7SD67), Neurospora crassa FGSC 987 (Q7SD67)
Manually annotated by BRENDA team
Li, S.; Ye, Z.; Moreb, E.A.; Hennigan, J.N.; Castellanos, D.B.; Yang, T.; Lynch, M.D.
Dynamic control over feedback regulatory mechanisms improves NADPH flux and xylitol biosynthesis in engineered E. coli
Metab. Eng.
64
26-40
2021
Escherichia coli (A0A0E3ZP28)
Manually annotated by BRENDA team